Rumen Development, Intestinal Growth and Hepatic Metabolism In The Pre- and Postweaning Ruminant

Feeding- and management-related diseases in the transition cow

Invited review: Effects of milk ration on solid feed intake, weaning, and performance in dairy heifers

Effect of Various Dietaries on the Anatomical Development of the Stomach in the Calf

Butyrate production in the large intestine and ruminant forestomach depends on bacterial butyryl-CoA/acetate-CoA transferase activity and is highest when fermentable fiber and nonstructural carbohydrates are balanced. Gastrointestinal epithelia seem to use butyrate and butyrate-induced endocrine signals to adapt proliferation, apoptosis, and differentiation to the growth of the bacterial community. Butyrate has a potential clinical application in the treatment of inflammatory bowel disease (IBD; ulcerative colitis). Via inhibited release of tumor necrosis factor α and interleukin 13 and inhibition of histone deacetylase, butyrate may contribute to the restoration of the tight junction barrier in IBD by affecting the expression of claudin-2, occludin, cingulin, and zonula occludens poteins (ZO-1, ZO-2). Further evaluation of the molecular events that link butyrate to an improved tight junction structure will allow for the elucidation of the cofactors affecting the reliability of butyrate as a clinical treatment tool.

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W. P. Flatt

Papers

Ruminant Nutrition, Dietary Factors Influencing Development of Ruminant Stomach

Influence of Purified Materials on the Development of the Ruminant Stomach

Evaluation of several techniques used in the study of developing rumen function.