W
Wael Abdo Hassan
Researcher at Suez Canal University
Publications - 39
Citations - 609
Wael Abdo Hassan is an academic researcher from Suez Canal University. The author has contributed to research in topics: Medicine & Notch signaling pathway. The author has an hindex of 10, co-authored 31 publications receiving 471 citations. Previous affiliations of Wael Abdo Hassan include Sulaiman Al Rajhi Colleges & Kumamoto University.
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Journal ArticleDOI
Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer.
Kosuke Fujino,Yamato Motooka,Wael Abdo Hassan,Wael Abdo Hassan,Mohamed Osama Ali Abdalla,Mohamed Osama Ali Abdalla,Yonosuke Sato,Shinji Kudoh,Koki Hasegawa,Kanako Niimori-Kita,Hironori Kobayashi,Ichiro Kubota,Joeji Wakimoto,Makoto Suzuki,Takaaki Ito +14 more
TL;DR: It is found that INSM1 was not expressed in non-small-cell lung cancer and some SCLC cell lines expressing Notch1-Hes1, and by forced/knockdown expression of Notch 1 or Hes1 genes, it was revealed that Notch2-HES1 signaling suppressed IN SM1, as well as ASCL1 and BRN2.
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The pathological significance of Notch1 in oral squamous cell carcinoma
Ryoji Yoshida,Masashi Nagata,Hideki Nakayama,Kanako Niimori-Kita,Wael Abdo Hassan,Wael Abdo Hassan,Takuji Tanaka,Masanori Shinohara,Takaaki Ito +8 more
TL;DR: Results indicate that altered expression of Notch1 is associated with increased cancer progression and that notch1 regulates the steps involved in cell metastasis in OSCC, and inactivating Notch signaling with GSI could therefore be a useful approach for treating patients with OSCC.
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Small cell lung cancer, an epithelial to mesenchymal transition (EMT)-like cancer: significance of inactive Notch signaling and expression of achaete-scute complex homologue 1
TL;DR: SCLC is characterized by neuroendocrine differentiation and EMT-like features, which could be produced by inactive Notch signaling and ASCL1 expression, which may determine the cell behaviors of SCLC partly through modifying EMT phenotypes.
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Notch1 controls cell invasion and metastasis in small cell lung carcinoma cell lines
TL;DR: The results demonstrate that activation of Notch1 signaling pathway may represent a new strategy for treating human SCLC, and notch1 controls cell adhesion and EMT.
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Evaluation of role of Notch3 signaling pathway in human lung cancer cells
TL;DR: Notch3 signaling in lung carcinoma is dependent on cell type, and inhibiting Notch3 inNSCLC decreases cell proliferation and induces apoptosis in NSCLC, while notch3 has no effect on cell proliferation or NE features of SCLC.