Showing papers by "Wafaa S. Hamama published in 1987"
TL;DR: The Mannich reaction of the title compound 1 with formaldehyde and morpholine, piperidine or piperazine afforded the Mannich bases 3-5 respectively, whereas the indeno[1.2-d]pyrimidines (6-7) were obtained where primary amines were used as discussed by the authors.
Abstract: Abstract Mannich reaction of the title compound 1 with formaldehyde and morpholine, piperidine or piperazine afforded the Mannich bases 3-5 respectively, whereas the indeno[1.2-d]pyrimidines (6-7) were obtained where primary amines were used. Treatment of 2 with formaldehyde gave benz[b]indeno-diazepine (8). The reaction of formaldehyde with 1 was also investigated.
6 citations
4 citations
3 citations
TL;DR: Schmidt reaction of the pyrazolo-β-(p-anisyl)-propionic acid as discussed by the authors gave a pyrazolamide and anisylethylamine, which were obtained via double Mannich reaction with the bis-Mannich base of cyclopentanone and transamination with gramine respectively.
Abstract: Schmidt reaction of the pyrazolo-β-(p-anisyl)-propionic acid 3 gave the pyrazolo-anisylethylamine 4. The related alkaloids 5 and 6 were obtained via double Mannich reaction of 4 with the bis-Mannich base of cyclopentanone and transamination with gramine respectively. The pyrazolo-phenylalanine 9 was obtained from the EAA adduct 7, through its Schmidt reaction to give 8 followed by hydrolysis, whereas the pyrazolo-amino acid 12 resulted from the hydrolysis of the corresponding lactam 11.
3 citations