Showing papers by "Wafaa S. Hamama published in 2007"
TL;DR: In this paper, a pyrido[2,3-d]pyrimidine incorporating 3,2'bis(quinoline) derivative was synthesized and pyridin with pyrazole or imidazole moieties was achieved via reaction of 1 with benzylidene derivatives of pyrazolone, imidazeolone or 3-carboethoxycoumarin to give 21, 22 and 24, respectively.
Abstract: The reaction of 6-aminouracil (1) with the appropriate α ,β -unsaturated ketones, gave the corresponding pyrido[2,3-d]pyrimidin-2,4-diones 3, 6, 8 and 10, respectively. Treatment of 1 with salicylaldehyde, 6-carboethoxy-3,5-diphenyl-2-cyclohexenone (13) or 2,6bis(phenylmethylidene)cyclohexanone (15) afforded the corresponding pyrimido[4,5-d]quinoline2,4-diones 12, 14 and 16, respectively. Furthermore, a pyrido[2,3-d]pyrimidine incorporating 3,2’bis(quinoline) derivative 18 was synthesized. Annulation of pyrido[2,3-d]pyrimidine with pyrazole or imidazole moieties was achieved via reaction of 1 with benzylidene derivatives of pyrazolone, imidazolone or 3-carboethoxycoumarin (23) to give 21, 22 and 24, respectively.
6 citations
TL;DR: In this article, a pyrido[2,3-d]pyrimidine incorporating 3,2'bis(quinoline) derivative was synthesized and pyridin with pyrazole or imidazole moieties was achieved via reaction of 1 with benzylidene derivatives of pyrazolone, imidazeolone or 3-carboethoxycoumarin to give 21, 22 and 24, respectively.
Abstract: The reaction of 6-aminouracil (1) with the appropriate α ,β -unsaturated ketones, gave the corresponding pyrido[2,3-d]pyrimidin-2,4-diones 3, 6, 8 and 10, respectively. Treatment of 1 with salicylaldehyde, 6-carboethoxy-3,5-diphenyl-2-cyclohexenone (13) or 2,6bis(phenylmethylidene)cyclohexanone (15) afforded the corresponding pyrimido[4,5-d]quinoline2,4-diones 12, 14 and 16, respectively. Furthermore, a pyrido[2,3-d]pyrimidine incorporating 3,2’bis(quinoline) derivative 18 was synthesized. Annulation of pyrido[2,3-d]pyrimidine with pyrazole or imidazole moieties was achieved via reaction of 1 with benzylidene derivatives of pyrazolone, imidazolone or 3-carboethoxycoumarin (23) to give 21, 22 and 24, respectively.
2 citations
TL;DR: In this paper, a review summarises the structure, basicity, asymmetric organocatalysis, synthesis and reactions of quinuclidines, which are bicyclic saturated pyridin-containing compounds with rigid structures and a ring-juncture nitrogen atom.
Abstract: This review summarises the structure, basicity, asymmetric organocatalysis, synthesis and reactions of quinuclidines. Quinuclidines are bicyclic saturated pyridin-containing compounds with rigid structures and a ring-juncture nitrogen atom. This review covers the period from 1984–2005.