W
Wai Yee Fong
Researcher at University of Liverpool
Publications - 5
Citations - 82
Wai Yee Fong is an academic researcher from University of Liverpool. The author has contributed to research in topics: Gene & Salmonella. The author has an hindex of 3, co-authored 4 publications receiving 51 citations.
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Journal ArticleDOI
Adding function to the genome of African Salmonella Typhimurium ST313 strain D23580.
Rocío Canals,Disa L. Hammarlöf,Carsten Kröger,Siân V. Owen,Wai Yee Fong,Lizeth Lacharme-Lora,Xiaojun Zhu,Nicolas Wenner,Sarah Carden,Jared Honeycutt,Denise M. Monack,Robert A. Kingsley,Philip Brownridge,Roy R. Chaudhuri,Will P. M. Rowe,Alexander V. Predeus,Karsten Hokamp,Melita A. Gordon,Melita A. Gordon,Jay C. D. Hinton +19 more
TL;DR: An in-depth genomic comparison between the ST313 isolate D23580 and the well-characterized ST19 isolate 4/74 that causes gastroenteritis across the globe revealed extensive synteny, highlighting the power of large-scale comparative multicondition analyses to pinpoint key phenotypic differences between bacterial pathovariants.
Journal ArticleDOI
The use of chicken and insect infection models to assess the virulence of African Salmonella Typhimurium ST313.
Lizeth Lacharme-Lora,Siân V. Owen,Siân V. Owen,R. Blundell,Rocío Canals,Nicolas Wenner,Blanca M. Perez-Sepulveda,Wai Yee Fong,Rachel Gilroy,Paul Wigley,Jay C. D. Hinton +10 more
TL;DR: These three infection models do not reproduce the characteristics of the systemic disease caused by S. Typhimurium ST313 in humans, according to a comprehensive analysis of all the chicken infection experiments.
Journal ArticleDOI
Complete Genome Sequences of African Salmonella enterica Serovar Enteritidis Clinical Isolates Associated with Bloodstream Infection.
Blanca M. Perez-Sepulveda,Alexander V. Predeus,Wai Yee Fong,Christopher M. Parry,J.S. Cheesbrough,Paul Wigley,Nicholas A. Feasey,Jay C. D. Hinton +7 more
TL;DR: The complete genome sequencing and annotation of four Salmonella enterica serovar Enteritidis isolates are reported, two that are representative of the Central/Eastern African clade (CP255 and D7795) and two from the Global EpidemicClade (A1636 and P125109).
Posted ContentDOI
Genome-wide fitness analysis identifies genes required for in vitro growth and macrophage infection by African and global epidemic pathovariants of Salmonella enterica Enteritidis
Wai Yee Fong,Rocío Canals,Alexander V. Predeus,Blanca M. Perez-Sepulveda,Nicolas Wenner,Lizeth Lacharme-Lora,Nicholas A. Feasey,Paul Wigley,Jay C. D. Hinton +8 more
TL;DR: The gene sets required for growth under laboratory conditions and macrophage infection by African and Global Epidemic S. Enteritidis were broadly similar, and that the majority of the genes that contribute to survival and replication in macrophages already have proven roles in Salmonella virulence.
Posted ContentDOI
Adding function to the genome of AfricanSalmonellaST313
Rocío Canals,Disa L. Hammarlöf,Carsten Kröger,Siân V. Owen,Wai Yee Fong,Lizeth Lacharme-Lora,Xiaojun Zhu,Nicolas Wenner,Sarah Carden,Jared Honeycutt,Denise M. Monack,Robert A. Kingsley,Philip Brownridge,Roy R. Chaudhuri,Will P. M. Rowe,Alexander V. Predeus,Karsten Hokamp,Melita A. Gordon,Jay C. D. Hinton +18 more
TL;DR: An in-depth genomic comparison between the ST313 isolate D23580, and the well-characterized ST19 isolate 4/74 that causes gastroenteritis across the globe, revealed extensive synteny between the two strains, highlighting the power of large-scale comparative multi-condition analyses to pinpoint key phenotypic differences between bacterial pathovariants.