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Walter Neupert
Researcher at Max Planck Society
Publications - 475
Citations - 48930
Walter Neupert is an academic researcher from Max Planck Society. The author has contributed to research in topics: Translocase of the inner membrane & Mitochondrion. The author has an hindex of 122, co-authored 474 publications receiving 47586 citations. Previous affiliations of Walter Neupert include Pierre-and-Marie-Curie University & Marquette University.
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Journal ArticleDOI
Translocation of proteins into mitochondria.
TL;DR: This review summarizes the present knowledge on the import and sorting of mitochondrial precursor proteins, with a special emphasis on unresolved questions and topics of current research.
Journal ArticleDOI
Protein import into mitochondria.
TL;DR: Molecular chaperones in the matrix exert multiple functions in translocation, sorting, folding, and assembly of newly imported proteins.
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Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria.
Ming Yuan Cheng,Franz-Ulrich Hartl,Jörg Martin,Robert A. Pollock,Frantisek Kalousek,Walter Neupert,Elisabeth M. Hallberg,Richard L. Hallberg,Arthur L. Horwich +8 more
TL;DR: A nuclear encoded mitochondrial heat-shock protein hsp60 is required for the assembly into oligomeric complexes of proteins imported into the mitochondrial matrix.
Journal ArticleDOI
Mitochondrial protein import.
TL;DR: Most mitochondrial proteins are synthesized as precursors on cytosolic polysomes and are subsequently imported into mitochondria as discussed by the authors, where they are stored on the outer membrane of the mitochondria.
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Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.
Pil-Jung Kang,Joachim Ostermann,Joachim Ostermann,Jeffery Shilling,Walter Neupert,Elizabeth A. Craig,Nikolaus Pfanner +6 more
TL;DR: By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the Matrix.