W
Wan-Sung Choi
Researcher at Gyeongsang National University
Publications - 6
Citations - 117
Wan-Sung Choi is an academic researcher from Gyeongsang National University. The author has contributed to research in topics: ASK1 & MAP kinase kinase kinase. The author has an hindex of 6, co-authored 6 publications receiving 111 citations.
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Journal ArticleDOI
Proteomic analysis reveals an elevated expression of heat shock protein 27 in preeclamptic placentas.
Jeong-Kyu Shin,Jong-Chul Baek,Min-Young Kang,Ji-Kwon Park,Soon-Ae Lee,Jong Hak Lee,Wan-Sung Choi,Won-Young Paik +7 more
TL;DR: The study confirmed that four proteins are upregulated and eight proteins are downregulated in preeclampsia, including signal transduction protein and molecular chaperon protein, in which Hsp27 is upregulated.
Journal ArticleDOI
Expression of clusterin in normal and preeclamptic placentas.
Jeong-Kyu Shin,Kyung An Han,Min-Young Kang,Y.H. Kim,Ji-Kwon Park,Wonjun Choi,Soon-Ae Lee,Jong Hak Lee,Wan-Sung Choi,Won-Young Paik +9 more
TL;DR: Clusterin is a multifunctional protein that is up‐regulated during many different pathophysiological states and may be related to a compensation mechanism involving aggregation of soluble proteins, inhibition of complement‐mediated cell damage, adaptive regeneration or apoptosis.
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Increased interaction between heat shock protein 27 and mitogen-activated protein kinase (p38 and extracellular signal-regulated kinase) in pre-eclamptic placentas.
Jeong-Kyu Shin,Young-Taek Jeong,Hyun-Cheol Jo,Min-Young Kang,In-Suk Chang,Jong-Chul Baek,Ji-Kwon Park,Soon-Ae Lee,Jong Hak Lee,Wan-Sung Choi,Won-Young Paik +10 more
TL;DR: Evaluated the interaction between Hsp27 and mitogen‐activated protein kinase (MAPK) (p38, extracellular signal‐regulated kinase [ERK], and c‐Jun N‐terminal kinase) in the human placenta derived from patients with pre‐eclampsia.
Journal ArticleDOI
Increased NFAT5 expression stimulates transcription of Hsp70 in preeclamptic placentas
J.K. Park,T.G. Kang,Min-Young Kang,Ji-Kwon Park,In Ae Cho,Jeong-Kyu Shin,Wan-Sung Choi,Su-Lim Lee,Wan Sung Choi,H.M. Kwon,Jungsub Lee,Won-Young Paik +11 more
TL;DR: HIF-1α positively regulates the induction of NFAT5 and Hsp70 by placental hypoxia andNFAT5 stimulates transcription of Hsp 70 in response to placentalhypoxia in models of human placental Hypoxia models in vitro.
Journal ArticleDOI
PKC δ in Preeclamptic Placentas Promotes Bax Dissociation from 14-3-3 ζ through 14-3-3 ζ Phosphorylation
J.K. Park,Min-Young Kang,Y.H. Kim,Hyen Chul Jo,Jeong-Kyu Shin,Wan-Sung Choi,Soon-Ae Lee,Jungsub Lee,Wan Sung Choi,Won-Young Paik +9 more
TL;DR: Preeclampsia is associated with higher levels of cleaved caspase-3, Bax, 14-3-3 zeta, phospho-(Ser)-14-3 -3, and PKC delta, which may at least in part explain the apoptosis-inducing activity of PKCDelta.