http://download.neurosky.com/docs/papers/bcq/Klimesch_1999_EEG_alpha_and_theta_oscillations_reflect_cognitive_and_memory_performance.pdf

EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis

Preface .............................................................. 649

The functional states of the thalamus and the associated neuronal interplay.

A monograph communicating the current realities and future possibilities of unifying basic studies on anatomy and cellular physiology with investigations of the behavioral and physiological events of waking and sleep. Steriade established the Laboratory of Neurophysiology at Laval U., Quebec; McCarl

Brainstem control of wakefulness and sleep

http://raphe.kaist.ac.kr/publication/2004-EEG%20dynamics%20in%20patients%20with%20Alzheimer’s%20disease.pdf

EEG dynamics in patients with Alzheimer's disease

Background: The cognitive continuum in the elderly population can be conceptually divided into those who are functioning normally (control subjects), those with a mild cognitive impairment (MCI), and those with probable AD. Objectives: To test the hypothesis that the annualized rates of hippocampal atrophy differ as a function of both baseline and change in clinical group membership (control, MCI, or AD). Methods: The authors identified 129 subjects from the Mayo Clinic AD Research Center/AD Patient Registry who met established criteria for normal control subjects, MCI, or probable AD, both at entry and at the time of a subsequent clinical follow-up evaluation 3 ± 1 years later. Each subject underwent an MRI examination of the head at the time of the initial assessment and at follow-up clinical assessment; the annualized percentage change in hippocampal volume was computed. Subjects who were classified as controls or patients with MCI at baseline could either remain cognitively stable or could decline to a lower functioning group over the period of observation. Results: The annualized rates of hippocampal volume loss for each of the three initial clinical groups decreased progressively in the following order: AD > MC > control. Within the control and MCI groups, those who declined had a significantly greater rate of volume loss than those who remained clinically stable. The mean annualized rates of hippocampal atrophy by follow-up clinical group were: control-stable 1.73%, control-decliner 2.81%, MCI-stable 2.55%, MCI-decliner 3.69%, AD 3.5%. Conclusion: Rates of hippocampal atrophy match both baseline cognitive status and the change in cognitive status over time in elderly persons who lie along the cognitive continuum from normal to MCI to AD.

Rates of hippocampal atrophy correlate with change in clinical status in aging and AD

A longitudinal EEG study of mild senile dementia of Alzheimer type: changes at 1 year and at 2.5 years☆

Frequency analysis of the resting awake EEG in mild senile dementia of Alzheimer type.

Forty-seven subjects 65 to 80 years of age, of whom 20 were demented and 27 were normal, were studied by computed tomography. Volumetric indices of ventricular (V%) and sulcal size (S%) were determined by pixel counts without knowledge of clinical status. V% was 5.30 (+/- 1.92) for the controls and 10.46 (+/- 4.78) for the demented subjects. S% was 6.14 (+/- 2.51) for the controls and 10.61 (+/- 3.32) for the demented subjects. In each case, differences between the two groups were significant (P less than 0.0001). When a subsample of 29 scans were analyzed using linear and volumetric measurements, the linear measurements showed less pronounced differences between the demented subjects and the controls. These findings explain the conflicting results of different investigators concerning variations in ventricular and sulcal size in dementia and normal aging.

Volumetric measurements of the cerebrospinal fluid spaces in demented subjects and controls.

Visual evoked potentials in mild senile dementia of alzheimer type

Studies involving linear measurements of ventricular size and a volumetric measurement of the cerebrospinal fluid (CSF) space were performed on elderly subjects with mild dementia of the Alzheimer type and on age-matched controls. Forty-five subjects were studied twice at a 1 year interval; linear ventricular measurements showed not only a greater degree but a more rapid evolution of brain atrophy in individuals with mild dementia as compared with controls. An additional 12 normal subjects were studied twice over a 1 year period with volumetric estimates of the CSF space, which demonstrated development of significant brain atrophy within 1 year, while linear measurements on the same scans showed no significant change. The volumetric method is regarded as a more sensitive indicator of brain volume and is potentially useful in further studies in dementia.

http://www.ajnr.org/content/ajnr/4/3/699.full.pdf

Warren L. Danziger

Papers

A longitudinal EEG study of mild senile dementia of Alzheimer type: changes at 1 year and at 2.5 years☆

Frequency analysis of the resting awake EEG in mild senile dementia of Alzheimer type.

Volumetric measurements of the cerebrospinal fluid spaces in demented subjects and controls.

Visual evoked potentials in mild senile dementia of alzheimer type

Aging, dementia, and brain atrophy: a longitudinal computed tomographic study.