Weam I. Zaky

TL;DR: The new method presented here screens the excreta/feces from hundreds of mosquitoes per pool and provides proof-of-concept for a practical alternative to traditional methodologies resulting in significant cost and labor savings, and has the potential to greatly reduce MX costs.

TL;DR: These findings suggest that B. malayi can be maintained in culture as a valid system for pharmacological and biological studies, at least for several days after removal from the host and adaptation to the new environment.

TL;DR: It is hypothesized that paralysis of pharyngeal pumping by ivermectin in filariae could result in deprivation of essential nutrients, especially iron, inducing a wide range of responses evidenced by altered gene expression, changes in metabolic pathways, and altered developmental states in embryos.

TL;DR: This point-of-collection diagnostic platform provides an alternative to cost-prohibitive column-dependent DNA extractions that are typically coupled to detection methodologies requiring advanced laboratory infrastructure and should increase the feasibility of molecular xenomonitoring within B. malayi-endemic locations.

TL;DR: Drug effects assessed using a transcriptomic approach support the hypothesis that FLBZ acts predominantly on rapidly dividing cells, and provides a basis for selecting molecular markers of drug-induced damage which may be of use in predicting efficaciousFLBZ regimens.