Northampton Community College

Abstract: A new titration calorimeter is described and results are presented for the binding of cytidine 2'-monophosphate (2'CMP) to the active site of ribonuclease A. The instrument characteristics include very high sensitivity, rapid calorimetric response, and fast thermal equilibration. Convenient software is available for instrument operation, data collection, data reduction, and deconvolution to obtain least-squares estimates of binding parameters n, delta H degree, delta S degree, and the binding constant K. Sample through-put for the instrument is high, and under favorable conditions binding constants as large as 10(8) M-1 can be measured. The bovine ribonuclease A (RNase)/2'CMP system was studied over a 50-fold range of RNase concentration and at two different temperatures. The binding constants were in the 10(5) to 10(6) M-1 range, depending on conditions, and heats of binding ca. -15,000 cal/mol. Repeat determinations suggested errors of only a few percent in n, delta H degree, and K values over the most favorable concentration range.

Abstract: The 2-Poisson model for term frequencies is used to suggest ways of incorporating certain variables in probabilistic models for information retrieval. The variables concerned are within-document term frequency, document length, and within-query term frequency. Simple weighting functions are developed, and tested on the TREC test collection. Considerable performance improvements (over simple inverse collection frequency weighting) are demonstrated.

Abstract: The linear image restoration problem is to recover an original brightness distribution X/sup 0/ given the blurred and noisy observations Y=KX/sup 0/+B, where K and B represent the point spread function and measurement error, respectively. This problem is typical of ill-conditioned inverse problems that frequently arise in low-level computer vision. A conventional method to stabilize the problem is to introduce a priori constraints on X/sup 0/ and design a cost functional H(X) over images X, which is a weighted average of the prior constraints (regularization term) and posterior constraints (data term); the reconstruction is then the image X, which minimizes H. A prominent weakness in this approach, especially with quadratic-type stabilizers, is the difficulty in recovering discontinuities. The authors therefore examine prior smoothness constraints of a different form, which permit the recovery of discontinuities without introducing auxiliary variables for marking the location of jumps and suspending the constraints in their vicinity. In this sense, discontinuities are addressed implicitly rather than explicitly. >

Abstract: Ninety-two mixed etiology neurological patients and 216 control participants were assessed on a range of neuropsychological tests, including 10 neuropsychological measures of executive function derived from 6 different tests. People who knew the patients well (relatives or carers) completed a questionnaire about the patient's dysexecutive problems in everyday life, and this paper reports the extent to which the tests predicted the patients' everyday life problems. All of the tests were significantly predictive of at least some of the behavioral and cognitive deficits reported by patients' carers. However, factor analysis of the patients' dysexecutive symptoms suggested a fractionation of the dysexecutive syndrome, with neuropsychological tests loading differentially on 3 underlying cognitive factors (Inhibition, Intentionality, and Executive Memory), supporting the conclusions that different tests measure different cognitive processes, and that there may be limits to the fractionation of the executive system.

Abstract: The concepts of ‘information literacy’ and ‘digital literacy’ are described, and reviewed, by way of a literature survey and analysis. Related concepts, including computer literacy, library literacy, network literacy, Internet literacy and hyper‐literacy are also discussed, and their relationships elucidated. After a general introduction, the paper begins with the basic concept of ‘literacy’, which is then expanded to include newer forms of literacy, more suitable for complex information environments. Some of these, for example library, media and computer literacies, are based largely on specific skills, but have some extension beyond them. They lead togeneral concepts, such as information literacy and digital literacy which are based on knowledge, perceptions and attitudes, though reliant on the simpler skills‐based literacies