W
Wei Ge
Researcher at University of Macau
Publications - 130
Citations - 4677
Wei Ge is an academic researcher from University of Macau. The author has contributed to research in topics: Zebrafish & Follistatin. The author has an hindex of 36, co-authored 121 publications receiving 3908 citations. Previous affiliations of Wei Ge include University of Alberta & National Institute for Basic Biology, Japan.
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Zebrafish Gonadotropins and Their Receptors: I. Cloning and Characterization of Zebrafish Follicle-Stimulating Hormone and Luteinizing Hormone Receptors— Evidence for Their Distinct Functions in Follicle Development
TL;DR: Differential roles for Fshr and Lhr in zebrafish ovarian follicle development are suggested, particularly after reaching the maximal level in the midvitellogenic follicles.
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Zebrafish Gonadotropins and Their Receptors: II. Cloning and Characterization of Zebrafish Follicle-Stimulating Hormone and Luteinizing Hormone Subunits—Their Spatial-Temporal Expression Patterns and Receptor Specificity
Wai-Kin So,Hin-Fai Kwok,Wei Ge +2 more
TL;DR: The present study systematically investigated gonadotropins in the zebrafish in terms of their structure, spatial-temporal expression patterns, and receptor specificity, providing a solid foundation for further studies on the physiological relevance of FSH and LH in theZebrafish, one of the top biological models in vertebrates.
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Genetic analysis of zebrafish gonadotropin (FSH and LH) functions by TALEN-mediated gene disruption.
TL;DR: Some well-known functions of FSH and LH in fish are confirmed while also providing evidence for novel functions, which would be difficult to reveal using traditional biochemical and physiological approaches.
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Disruption of Zebrafish Follicle-Stimulating Hormone Receptor (fshr) But Not Luteinizing Hormone Receptor (lhcgr) Gene by TALEN Leads to Failed Follicle Activation in Females Followed by Sexual Reversal to Males.
TL;DR: Fshr was indispensable to folliculogenesis and the disruption of the fshr gene resulted in a complete failure of follicle activation followed by masculinization into males, which showed that lhcgr does not seem to be essential to zebrafish reproduction in both males and females.
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Knockout of Zebrafish Ovarian Aromatase Gene (cyp19a1a) by TALEN and CRISPR/Cas9 Leads to All-male Offspring Due to Failed Ovarian Differentiation.
TL;DR: Analysis showed that the ovarian aromatase did not seem to affect the formation of so-called juvenile ovary and oocyte-like germ cells; however, it was essential for further differentiation of the juvenile Ovary into the true ovary.