W
Wei J. Gong
Researcher at University of Utah
Publications - 6
Citations - 705
Wei J. Gong is an academic researcher from University of Utah. The author has contributed to research in topics: Gene targeting & Homologous recombination. The author has an hindex of 5, co-authored 5 publications receiving 677 citations. Previous affiliations of Wei J. Gong include Stowers Institute for Medical Research.
Papers
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Journal ArticleDOI
Ends-out, or replacement, gene targeting in Drosophila
Wei J. Gong,Kent G. Golic +1 more
TL;DR: It is found that ends-out targeting can be approximately as efficient as ends-in targeting, and is likely to be generally useful for Drosophila gene targeting.
Journal ArticleDOI
Loss of Hsp70 in Drosophila Is Pleiotropic, With Effects on Thermotolerance, Recovery From Heat Shock and Neurodegeneration
Wei J. Gong,Kent G. Golic +1 more
TL;DR: It is found that Hsp70 is essential to survive a severe heat shock, but is not required to survived a milder heatshock, indicating that a significant degree of thermotolerance remains in the absence of HSp70.
Journal ArticleDOI
Genomic Deletions of the Drosophila melanogaster Hsp70 Genes
Wei J. Gong,Kent G. Golic +1 more
TL;DR: The results show that genomic deletions of varied sizes can be readily generated by homologous recombination in Drosophila, including one deletion that spanned ∼47 kb.
Book ChapterDOI
Methods for homologous recombination in Drosophila.
TL;DR: Two methods of gene targeting in Drosophila are presented, identical in concept to gene replacement techniques used routinely in mammalian and yeast cells, but each method has separate strengths and drawbacks.
Patent
Ends-out gene targeting method
Kent G. Golic,Wei J. Gong +1 more
TL;DR: In this paper, the endonuclease and recombinase enzymes are used so that homologous recombination occurs between the DNA segment of the donor construct and a selected gene of the host organism, thus forming a host with containing the recombinogenic donor.