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Wei-Ling Tsou
Researcher at Wayne State University
Publications - 20
Citations - 562
Wei-Ling Tsou is an academic researcher from Wayne State University. The author has contributed to research in topics: Spinocerebellar ataxia & Neurodegeneration. The author has an hindex of 11, co-authored 16 publications receiving 405 citations. Previous affiliations of Wei-Ling Tsou include National Yang-Ming University.
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Journal ArticleDOI
An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes
TL;DR: The argument that understanding the UPP from the perspective of DUBs can yield new insight into diseases that result from anomalous intra- cellular processes or inter-cellular networks is made.
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Nanoplastics impact the zebrafish (Danio rerio) transcriptome: Associated developmental and neurobehavioral consequences.
Adam F. Pedersen,Danielle N. Meyer,Anna-Maria V. Petriv,Abraham L. Soto,Jeremiah N. Shields,Camille Akemann,Bridget B. Baker,Wei-Ling Tsou,Yongli Zhang,Tracie R. Baker +9 more
TL;DR: Results of this study suggest that NPs can accumulate in the tissues of larval zebrafish, alter their transcriptome, and affect behavior and physiology, potentially decreasing organismal fitness in contaminated ecosystems.
Journal ArticleDOI
Systematic analysis of the physiological importance of deubiquitinating enzymes
Wei-Ling Tsou,Michael J. Sheedlo,Marie E. Morrow,Jessica R. Blount,Kelly M. McGregor,Chittaranjan Das,Sokol V. Todi +6 more
TL;DR: The physiological significance of the DUB family of enzymes in intact animals is demonstrated, there is little functional redundancy among members of this family of proteases, and insight is provided for future investigations to understand DUB biology at the molecular, cellular and organismal levels.
Journal ArticleDOI
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23
Jessica R. Blount,Wei-Ling Tsou,Gorica Ristic,Aaron A. Burr,Michelle Ouyang,Holland Galante,K. Matthew Scaglione,Sokol V. Todi +7 more
TL;DR: It is shown that, unlike most proteins, ataxin-3 turnover does not require its ubiquitination, but is regulated by Ubiquitin-Binding Site 2 (UbS2) on its N terminus, and that UbS2 is a potential target through which to enhance ataxIn-3 degradation for SCA3 therapy.
Journal ArticleDOI
Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo.
Wei-Ling Tsou,Aaron A. Burr,Michelle Ouyang,Jessica R. Blount,K. Matthew Scaglione,Sokol V. Todi +5 more
TL;DR: It is reported that ubiquitination of the DUB ataxin-3 at lysine residue 117, which markedly enhances its protease activity in vitro, is critical for its ability to suppress toxic protein-dependent degeneration in Drosophila melanogaster.