Showing papers by "Wei Wang published in 2017"
TL;DR: The progress of diverse gossypol derivatives and analogs' synthesis, biological activities, mechanism elucidation and drug discovery based on gOSSypol scaffold is summarized.
Abstract: Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic contexts for a long time. The chemical modifications on gossypol were limited due to the unique chemical properties of polyphenols. The design and synthesis of gossypol derivatives and the exploration of their biological activities are the interest of the synthetic chemists, medicinal chemists and pharmacologists. Thus, the progress of diverse gossypol derivatives and analogs’ synthesis, biological activities, mechanism elucidation and drug discovery based on gossypol scaffold is summarized.
40 citations