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Wei Xu
Researcher at Queen's University
Publications - 19
Citations - 802
Wei Xu is an academic researcher from Queen's University. The author has contributed to research in topics: Perinuclear theca & Sperm. The author has an hindex of 12, co-authored 19 publications receiving 692 citations.
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Journal ArticleDOI
PAWP, a Sperm-specific WW Domain-binding Protein, Promotes Meiotic Resumption and Pronuclear Development during Fertilization * ♦
Alexander T.H. Wu,Peter Sutovsky,Gaurishankar Manandhar,Wei Xu,Mika Katayama,Billy N. Day,Kwang-Wook Park,Young-Joo Yi,Yanwei Xi,Randall S. Prather,Richard Oko +10 more
TL;DR: A group I WW domain module signal transduction event within the fertilized egg that appears compulsory for meiotic resumption and pronuclear development during egg activation is uncovered and provides compelling evidence that a PPXY motif of sperm-contributed PAWP can trigger these events.
Journal ArticleDOI
The extracellular protein coat of the inner acrosomal membrane is involved in zona pellucida binding and penetration during fertilization: characterization of its most prominent polypeptide (IAM38).
TL;DR: A novel approach is devised to obtain direct information on the peripheral and integral protein composition of the IAM for identifying other candidates for sperm-zona interactions and identifies IAM38 as the equivalent of porcine Sp38.
Journal ArticleDOI
MMP2 and acrosin are major proteinases associated with the inner acrosomal membrane and may cooperate in sperm penetration of the zona pellucida during fertilization
TL;DR: This is the first study to demonstrate that MMP2 and acrosin are associated with the IAM and introduces the possibility of their cooperation in enzymatic digestion of the ZP during penetration.
Journal ArticleDOI
The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport.
Alexander T.H. Wu,Peter Sutovsky,Wei Xu,Aarnoud C. van der Spoel,Frances M. Platt,Richard Oko +5 more
TL;DR: The same temporal and manchette-based pattern of PAWP-PAS assembly during spermiogenesis was evident as in controls supporting the hypothesis that PAS assembly is independent of subacrosomal PT formation and that egg-activating ability resides within the PAS.
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Sperm‐borne protein, PAWP, initiates zygotic development in Xenopus laevis by eliciting intracellular calcium release
TL;DR: Evidence for the first time is provided that sperm‐anchored PAWP is a primary initiator of zygotic development and the ability of the competitive peptide in blocking both sperm‐ and PAWP‐induced calcium release is provided.