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Weiguo Lu
Researcher at Zhejiang University
Publications - 175
Citations - 4037
Weiguo Lu is an academic researcher from Zhejiang University. The author has contributed to research in topics: Cervical cancer & Cervical intraepithelial neoplasia. The author has an hindex of 28, co-authored 170 publications receiving 3044 citations.
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Journal ArticleDOI
miR-375 Is Down-Regulated in Squamous Cervical Cancer and Inhibits Cell Migration and Invasion via Targeting Transcription Factor SP1
Fenfen Wang,Yang Li,Jiansong Zhou,Junfen Xu,Chanjuan Peng,Feng Ye,Yuanming Shen,Weiguo Lu,Xiaoyun Wan,Xing Xie +9 more
TL;DR: The findings suggest that down-regulated miR-375 promotes cell malignant behaviors via the target gene SP1 and may consequently contribute to the progression of cervical cancer.
Journal ArticleDOI
Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29†
Yang Li,Fenfen Wang,Junfen Xu,Feng Ye,Yuanming Shen,Jiansong Zhou,Weiguo Lu,Xiaoyun Wan,Ding Ma,Xing Xie +9 more
TL;DR: The results suggest that HPVs have oncogenic properties at least in part by reshaping the milieu of cellular miRNAs, although the abnormality of miR‐29 in HPV‐infected cells might be regulated in an indirect way.
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TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.
Songfa Zhang,Xinyu Wang,Zhiqin Fu,Qiaohua Peng,Jian-Yang Zhang,Feng Ye,Yunfeng Fu,Caiyun Zhou,Weiguo Lu,Xiaodong Cheng,Xing Xie +10 more
TL;DR: The findings suggest that TXNDC17, through participation of BECN1, induces autophagy and consequently results in paclitaxel resistance in ovarian cancer.
Journal ArticleDOI
VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinoma.
TL;DR: Results indicate that VEGF secreted by ovarian carcinomas cells may activate STAT pathway via VEGFRs in ovarian carcinoma themselves, and there exist overexpressions of V EGF, V EGFRs, and STAT3, STAT5 activation.
Journal ArticleDOI
The application of deep learning based diagnostic system to cervical squamous intraepithelial lesions recognition in colposcopy images
Chunnv Yuan,Yao Yeli,Bei Cheng,Yi-fan Cheng,Ying Li,Yang Li,Liu Xuechen,Xiaodong Cheng,Xing Xie,Jian Wu,Xinyu Wang,Weiguo Lu +11 more
TL;DR: Compared to colposcopists, the deep learning-based diagnostic system performed better in ordinary colposcopy images but slightly unsatisfactory in high-definition images, which could help assist colpos copy diagnosis and biopsy for HSILs.