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Weihong Gu
Researcher at Harbin Veterinary Research Institute
Publications - 12
Citations - 229
Weihong Gu is an academic researcher from Harbin Veterinary Research Institute. The author has contributed to research in topics: Virus & Porcine reproductive and respiratory syndrome virus. The author has an hindex of 6, co-authored 9 publications receiving 154 citations. Previous affiliations of Weihong Gu include University of Florida.
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Journal ArticleDOI
Tight Junction Protein Occludin Is a Porcine Epidemic Diarrhea Virus Entry Factor.
TL;DR: It is found that PEDV infection of epithelial cells results in disruption of the tight junctional distribution of occludin to its intracellular location, and genetic modification methods demonstrate that occlUDin plays an essential role in P EDV infection at the postbinding stages.
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Autophagy Negatively Regulates Transmissible Gastroenteritis Virus Replication
Longjun Guo,Haidong Yu,Weihong Gu,Xiaolei Luo,Ren Li,Jian Zhang,Yunfei Xu,Lijun Yang,Nan Shen,Li Feng,Yue Wang +10 more
TL;DR: It is found that TGEV infection increased the number of autophagosome-like double- and single-membrane vesicles in the cytoplasm of host cells, a phenomenon that is known to be related to autophagy.
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Modulation of CD163 Expression by Metalloprotease ADAM17 Regulates Porcine Reproductive and Respiratory Syndrome Virus Entry
Longjun Guo,Junwei Niu,Haidong Yu,Weihong Gu,Ren Li,Xiaolei Luo,Mingming Huang,Zhi-Jun Tian,Li Feng,Yue Wang +9 more
TL;DR: It is demonstrated for the first time that inhibition of ADAM17 enhances PRRSV entry in Marc-145 and porcine alveolar macrophages (PAMs) and downregulates CD163 expression and hinders PR RSV entry, indicating that downregulation of ADam17 particular substrates may be an additional component of the anti-infection defenses.
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Involvement of CD16 in antibody-dependent enhancement of porcine reproductive and respiratory syndrome virus infection.
Weihong Gu,Longjun Guo,Haidong Yu,Junwei Niu,Mingming Huang,Xiaolei Luo,Ren Li,Zhi-Jun Tian,Li Feng,Yue Wang +9 more
TL;DR: This work found that subneutralizing serum could induce ADE of PRRSV infection in porcine alveolar macrophages (PAMs), and demonstrated that CD16 is involved in enhanced virus production in PR RSV-antibody immune complex-infected PAMs, and showed that efficient expression of CD16 required association of the FcR γ-chain.
Journal ArticleDOI
Modulation of Immune Responses to Influenza A Virus Vaccines by Natural Killer T Cells.
John P. Driver,Darling Melany de Carvalho Madrid,Weihong Gu,Bianca Libanori Artiaga,Jürgen A. Richt +4 more
TL;DR: The factors that influence the adjuvant effects of iNKT cells for influenza vaccines as well as the obstacles that must be overcome before this novel adjUvant approach can be considered for human or veterinary use are discussed.