Weijian Chen

TL;DR: This study constructs a block copolymer prodrug-based polymersome nanoreactor that can achieve novel orchestrated oxidation/chemotherapy of cancer via specific activation at tumor sites and provides a new strategy for engineering therapeutic nanoreactors in an orchestrated fashion for cancer therapy.

TL;DR: In this article, the authors developed integrated nanoparticles to remold tumor microenvironment via specific amplification of the tumor oxidative stress and simultaneously realize ROS-responsive drug release, which has been frequently explored as the specific stimulus to trigger drug release.

TL;DR: An integrated multifunctional polymeric nanoparticle which can selectively improve hydrogen peroxide levels in tumor tissue and convert them into more active hydroxyl radicals by Fenton reaction is constructed.

TL;DR: A robust and facile strategy based on thiolactone chemistry to fabricate well-defined BCPs with sequential tumor pH-promoted cellular internalization and intracellular stimuli-responsive drug release is reported.

TL;DR: The strategy by facile incorporation of a responsive peptide linkage between PEG and PDLLA is a promising approach to improving the therapeutic efficacy of anticancer-drug-loaded amphiphilic block copolymer micelles.