W
Weiju Sun
Researcher at University of South Florida
Publications - 2
Citations - 81
Weiju Sun is an academic researcher from University of South Florida. The author has contributed to research in topics: Cardiac function curve & Muscle hypertrophy. The author has an hindex of 2, co-authored 2 publications receiving 33 citations.
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Journal ArticleDOI
SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion.
Ying Han,Weiju Sun,Di Ren,Jingwen Zhang,Zhibin He,Julia Fedorova,Xiaodong Sun,Fang Han,Ji Li +8 more
TL;DR: Results indicate that SIRT1 agonism can inhibit activation of NLRP3 inflammasome via Akt-dependent metabolic regulation during ischemic insults by I/R.
Journal ArticleDOI
Substrate metabolism regulated by Sestrin2-mTORC1 alleviates pressure overload-induced cardiac hypertrophy in aged heart.
TL;DR: Cardiac Sesn2 acts as a pressure overload sensor for mTORC1 and may cause increased sensitivity to hypertrophy in elderly individuals, and adeno-associated virus 9–SESn2 treatment rescued SesN2 expression, attenuated mTOR C1 activation, and increased pressure overload tolerance in aged WT and Y-Sesn 2 KO hearts.