J
Jingwen Zhang
Researcher at University of South Florida
Publications - 14
Citations - 700
Jingwen Zhang is an academic researcher from University of South Florida. The author has contributed to research in topics: Ischemia & Oxidative stress. The author has an hindex of 9, co-authored 12 publications receiving 459 citations. Previous affiliations of Jingwen Zhang include Shandong Normal University & University of Louisville.
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Journal ArticleDOI
miR-301a as an NF-κB activator in pancreatic cancer cells.
Zhongxin Lu,Yan Li,Apana Takwi,Benhui Li,Jingwen Zhang,Daniel J. Conklin,Ken H. Young,Robert C.G. Martin,Yong Li +8 more
TL;DR: It is demonstrated that miR‐301a down‐regulates NF‐κB‐repressing factor (Nkrf) and elevates NF‐σκB activation, which supports a positive feedback loop as a mechanism for persistent NF‐γB activation.
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Empagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet-Induced Obese Mice.
Xiaodong Sun,Fang Han,Qingguo Lu,Qingguo Lu,Xuan Li,Di Ren,Di Ren,Jingwen Zhang,Jingwen Zhang,Ying Han,Ying Han,Yang Kevin Xiang,Ji Li +12 more
TL;DR: EMPA improved obesity-related cardiac dysfunction via regulating Sestrin2-mediated AMPK-mTOR signaling and maintaining redox homeostasis and provides a novel mechanism for the cardiovascular protection of SGLT2i in obesity.
Journal ArticleDOI
A statin‐regulated microRNA represses human c‐Myc expression and function
Apana Takwi,Yan Li,Lindsey E. Becker Buscaglia,Jingwen Zhang,Saibyasachi N. Choudhury,Ae Kyung Park,Mo-Fang Liu,Ken H. Young,Woong-Yang Park,Robert C.G. Martin,Yong Li +10 more
TL;DR: This work identified miR‐33b as a primate‐specific negative regulator of c‐Myc, and presents a highly promising therapeutic option, using drug repurposing and a miRNA as a biomarker, against cancers that overexpress c‐ myc.
Journal ArticleDOI
SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion.
Ying Han,Weiju Sun,Di Ren,Jingwen Zhang,Zhibin He,Julia Fedorova,Xiaodong Sun,Fang Han,Ji Li +8 more
TL;DR: Results indicate that SIRT1 agonism can inhibit activation of NLRP3 inflammasome via Akt-dependent metabolic regulation during ischemic insults by I/R.
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Empagliflozin attenuates ischemia and reperfusion injury through LKB1/AMPK signaling pathway.
TL;DR: The results demonstrated that EMPA treatment significantly improves cardiomyocyte contractility under hypoxia conditions and augments the post-ischemic recovery in the ex vivo heart perfusion system.