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Weiwen Sun
Researcher at Guangzhou Medical University
Publications - 37
Citations - 693
Weiwen Sun is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Neuroprotection & Medicine. The author has an hindex of 15, co-authored 30 publications receiving 542 citations. Previous affiliations of Weiwen Sun include Chinese Ministry of Education.
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Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre‐conditioning in adult rats
TL;DR: In this article, the role of Akt/forkhead transcription factor, class O (FoxO) pathway in hypoxic pre-conditioning (HPC) using a newly developed HPC to transient global cerebral ischemia (tGCI) model in adult rats HPC for 30-120min significantly reduced cell death in the CA1 subregion after 10min of tGCI.
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Study of antiepileptic effect of extracts from Acorus tatarinowii Schott.
TL;DR: Theoretical studies of the antiepileptic properties of extracts from rhizomes of Acorus tatarinowii Schott reveal polypeptide-like properties that are similar to those of morphine and heroin.
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Hypoxia-inducible factor 1α mediates neuroprotection of hypoxic postconditioning against global cerebral ischemia.
Tingna Zhu,Lixuan Zhan,Donghai Liang,Donghai Liang,Jiaoyue Hu,Zhiwei Lu,Xinyong Zhu,Weiwen Sun,Liu Liu,En Xu +9 more
TL;DR: It is suggested that Hif-1&agr; exerts neuroprotection induced by HPC against tGCI through VEGF upregulation and cleaved caspase-9 downregulation, and that the PI3K, p38 MAPK, and MEK pathways are involved in the regulation of HIF-1 &agR; and VEGf.
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Autophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats.
Lixuan Zhan,Siyuan Chen,Kongping Li,Donghai Liang,Xinyong Zhu,Liu Liu,Zhiwei Lu,Weiwen Sun,En Xu +8 more
TL;DR: It is found that HPC attenuated AP accumulation in the hippocampal CA1 region after tGCI via restoration of autophagic flux, and results indicated that AP maturation was enhanced by the activation of Rab7 via UVRAG-Vps16 interaction, which further demonstrated the potential neuroprotective role of Rab 7 in HPC against t GCI-induced neuronal injury in adult rats.
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Activation of Akt/FoxO and inactivation of MEK/ERK pathways contribute to induction of neuroprotection against transient global cerebral ischemia by delayed hypoxic postconditioning in adult rats.
TL;DR: The results suggest that delayed HPC exerts neuroprotection against tGCI-induced injury in adult rats and investigates underlying mechanisms involving the Akt/Forkhead transcription factor, class O (FoxO) and mitogen-activated protein kinase kinase Kinase (MEK)/extracellular signal-regulated kinase (ERK) pathways.