Wen-Chih Chiang

TL;DR: PDGFR signaling is involved in pericyte activation, proliferation, and differentiation into myofibroblasts during progressive kidney injury and pericytes may be a novel target to prevent kidney fibrosis by means of PDG FR signaling blockade.

TL;DR: The results reveal that AKI with recovery associated with higher long-term risks of coronary events and death in this cohort is suggested, suggesting thatAKI may identify patients with high risk of future coronary events.

TL;DR: It is shown that cross talk between pericytes and endothelial cells concomitantly dictates development of fibrosis and loss of microvasculature after injury, and fibrogenesis inextricably with microvascular rarefaction for the first time, adding new significance to fibrogensesis, and identifying novel therapeutic targets.

TL;DR: A novel link between injured epithelium and pericyte-myofibroblast transition through TGF-β1 during kidney fibrosis is identified.

TL;DR: In a large cohort of postoperative patients who developed AKI, those with existing CKD were at higher risk for long-term mortality and dialysis after hospital discharge than those without and outcomes were significantly worse in those with unresolved AKI at discharge.