1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry

Many compounds containing a five-membered heterocyclic ring display exceptional chemical properties and versatile biological activities. In this Minireview, thiadiazoles are summarized according to their therapeutic potential, highlighting the versatility of this scaffold in medicinal chemistry. The unique properties of thiadiazoles are also discussed in relation to their potential effect on activity. Thiadiazole is a bioisostere of pyrimidine and oxadiazole, and given the prevalence of pyrimidine in nature it is unsurprising that thiadiazoles exhibit significant therapeutic potential. The sulfur atom of the thiadiazole imparts improved liposolubility, and the mesoionic nature of thiadiazoles makes these compounds better able to cross cellular membranes. By summarizing the thiadiazole-containing compounds reported in recent decades, we aim to give a brief introduction to their synthesis and diverse biological activities, such as anti-inflammatory, anticancer, antibacterial, antifungal, antiviral, antiparasitic, anticonvulsant, anticoagulant, antidiabetic, and to show the significant utility of the thiadiazole scaffolds in medicinal chemistry.

Thiadiazole-a promising structure in medicinal chemistry.

Recent advances of cytotoxic chalconoids targeting tubulin polymerization: Synthesis and biological activity.

Phenylpropanoids and their derivatives are plant secondary metabolites widely present in fruits, vegetables, cereal grains, beverages, spices and herbs. They are known to have multifaceted effects which include antimicrobial, antioxidant, anti-inflammatory, antidiabetic, anticancer activities and as well as exhibits renoprotective, neuroprotective, cardioprotective and hepatoprotective effects. Owing to their antioxidant, antimicrobial and photoprotective properties, these compounds have wide application in the food (preservation, packaging films and edible coating), pharmaceutical, cosmetic and other industries such as textile (colorant), biofuel (antioxidant additive) and sensors (sensing biologically relevant molecules). Phenylpropanoids are present in commercially available dietary supplements and skin care products. In this review, we have presented the current knowledge on the biosynthesis, occurrence, biological activities of phenylpropanoids and their derivatives, along with the mechanism of action and their potential applications in various industries.

Phenylpropanoids and its derivatives: biological activities and its role in food, pharmaceutical and cosmetic industries.

1,3,4-Trisubstituted pyrazole analogues as promising anti-inflammatory agents.

Synthesis, biological evaluation, and molecular docking studies of cinnamic acyl 1,3,4-thiadiazole amide derivatives as novel antitubulin agents.

Provided are (1, 3-diphenyl-1hydrogen-4-pyrazolyl) methyl benzoic acid derivatives which are characterized by the following general formula:, wherein R1 can be 4-fluorine, chlorine, hydrogen, methyl and methoxy group, and R2 can be 4-fluorine, chlorine, hydrogen and methoxy group The derivatives can inhibit multiplication of mouse melanoma A375 cell line, and so the derivatives can be used as potential anti-melanoma medicines The invention discloses a preparation method for the compounds

Wen Qing

Papers

Synthesis, biological evaluation, and molecular docking studies of cinnamic acyl 1,3,4-thiadiazole amide derivatives as novel antitubulin agents.

Preparation of (1, 3-diphenyl-1hydrogen-4-pyrazolyl) methyl benzoic acid serial compounds and applications in treatment of melanoma