Wen Yin

TL;DR: The fundamental roles of biofilm in protecting microbial exposure to extreme environmental stresses and the regulatory factors involved in biofilm formation are described.

TL;DR: The key role of c-di-AMP in maintaining bacterial osmotic balance, especially in Gram-positive bacteria is emphasized, and the future directions and trends of the c- Di-AMP regulatory network are discussed, such as the likely existence of potential c-Di-AMP transporter(s), the possibility of crosstalk between c- di-AMP signaling with other regulatory systems, andThe effects of c

TL;DR: This work describes seven kinds of non-covalent-π interactions between c-di-AMP and its receptor proteins, including π-π, C-H- π, cation-δ, polar- ρ, hydrophobic-κ, anion-π and the lone pair-π interaction, and compares these two cyclic dinucleotides to control very different biological functions.

TL;DR: In this article, the authors classify the current strategies into three main categories: (i) changing the properties of susceptible surfaces to prevent biofilm formation; (ii) regulating signalling pathways to inhibit biofilm forming; (iii) applying external forces to eradicate the biofilm.

TL;DR: It is reported that the transcription of a kdpFABC operon is distinctively regulated by a cyclic diadenylate monophosphate (c-di-AMP) riboswitch located at the 5′-untranslated region of kdp transcript, and binding of c- di-AMP to the Riboswitch promotes its intrinsic termination that blocks the kdp FABC transcription.