Wen Zheng

TL;DR: The interplay of mitochondrial hyperacetylation and inflammation as a key driver in HFpEF pathogenesis is identified and can be ameliorated by promoting β-hydroxybutyrate abundance.

TL;DR: A powerful and user-friendly web platform, named MetaboGroup S, is presented for comparison and evaluation of seven popular normalization methods and provides an optimal one automatically for end users based on the group entropies of every sample data point.

TL;DR: This work develops a free interactive web software platform, MixProTool, for processing multigroup proteomics data sets, which provides integrated data analysis workflow, including quality control assessment, normalization, soft independent modeling of class analogy, statistics, gene ontology enrichment, and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis.

TL;DR: Results indicated that —high concentrations (500 mg/L) of MXene can cause significant changes in the energy metabolism of HUVECs, showing obvious inhibition of tricarboxylic acid (TCA) cycle with the enhancement of glycolysis, fatty acid biosynthesis, and lipid accumulation.

TL;DR: A novel potential mechanism of HDV-induced liver injury and hepatocarcinogenesis is revealed: s-HDAg can inhibit GSTP1 expression by directly binding to GSTP 1 mRNA, which leads to accumulation of cellular ROS, resulting in high cellular apoptotic ratios and increased selective pressure for malignant transformation.