Wendy Baur

TL;DR: This UCP1-TRAP data set demonstrates striking similarities and important differences between these cell types, including a smooth muscle-like signature expressed by beige, but not classical brown, adipocytes.

TL;DR: Striatin is identified as a molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways and provides conceptual support for the potential development of "pathway-specific" selective ER modulators.

TL;DR: It is shown that human coronary artery and aortic ECs express MR mRNA and protein and that EC MR mediates aldosterone-dependent gene transcription, and that ald testosterone activates endogenous EC MR and proatherogenic gene expression in clinically important human ECs.

TL;DR: Data support that although the ROCK isoforms both regulate MLCP and myosin light chain phosphorylation through different mechanisms, they have distinct roles in VSMC function.

TL;DR: It is shown that mice with a selective mutation in the N-terminal protein interaction domain of PKGIα display inherited vascular smooth muscle cell abnormalities of contraction, abnormal relaxation of large and resistance blood vessels, and increased systemic blood pressure, suggesting a new approach to the diagnosis and therapy of hypertension and cardiovascular diseases.