W
Wenli Zheng
Researcher at The Chinese University of Hong Kong
Publications - 12
Citations - 1080
Wenli Zheng is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Aneuploidy & Haplotype. The author has an hindex of 3, co-authored 12 publications receiving 1004 citations.
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Journal ArticleDOI
Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma.
Rossa W.K. Chiu,K.C. Allen Chan,Yuan Gao,Virginia Y. M. Lau,Wenli Zheng,Tak Yeung Leung,Chris H. F. Foo,Bin Xie,Nancy B.Y. Tsui,Fiona M.F. Lun,Benny Zee,Tze K. Lau,Charles R. Cantor,Y.M. Dennis Lo +13 more
TL;DR: Massively parallel plasma DNA sequencing represents a new approach that is potentially applicable to all pregnancies for the noninvasive prenatal diagnosis of fetal chromosomal aneuploidies.
Patent
Size-based genomic analysis
TL;DR: In this paper, a system, methods, and apparatuses for performing a prenatal diagnosis of a sequence imbalance are provided, where a shift (e.g. to a smaller size distribution) can signify an imbalance in certain circumstances.
Patent
Size-based analysis of fetal dna fraction in maternal plasma
TL;DR: In this article, the fractional concentration of clinically-relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments at multiple sizes, and a comparison of the first value to the calibration data points can provide the estimate of the proportion of clinically relevant DNA.
Patent
Size-based analysis of tumor dna
TL;DR: In this article, a first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes, and the first value is compared to a reference value.
Patent
Size-based analysis of fetal or tumor DNA fraction in plasma
TL;DR: In this article, the fractional concentration of clinically-relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments at multiple sizes at different sizes.