R
Rossa W.K. Chiu
Researcher at The Chinese University of Hong Kong
Publications - 285
Citations - 24536
Rossa W.K. Chiu is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Prenatal diagnosis & Cell-free fetal DNA. The author has an hindex of 73, co-authored 276 publications receiving 21506 citations. Previous affiliations of Rossa W.K. Chiu include Royal Brisbane and Women's Hospital.
Papers
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Journal ArticleDOI
Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma.
Rossa W.K. Chiu,K.C. Allen Chan,Yuan Gao,Virginia Y. M. Lau,Wenli Zheng,Tak Yeung Leung,Chris H. F. Foo,Bin Xie,Nancy B.Y. Tsui,Fiona M.F. Lun,Benny Zee,Tze K. Lau,Charles R. Cantor,Y.M. Dennis Lo +13 more
TL;DR: Massively parallel plasma DNA sequencing represents a new approach that is potentially applicable to all pregnancies for the noninvasive prenatal diagnosis of fetal chromosomal aneuploidies.
Journal ArticleDOI
Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus
Y.M. Dennis Lo,K.C. Allen Chan,Hao Sun,Eric Z. Chen,Peiyong Jiang,Fiona M.F. Lun,Yama W. Zheng,Tak Yeung Leung,Tze K. Lau,Charles R. Cantor,Rossa W.K. Chiu +10 more
TL;DR: This study shows that sequencing of maternal plasma DNA provides a way for noninvasive prenatal genome- wide scanning for genetic disorders and suggests the feasibility of using genome-wide scanning to diagnose fetal genetic disorders prenatally in a noninvasively way.
Journal ArticleDOI
Detection and characterization of placental microRNAs in maternal plasma.
Stephen S.C. Chim,Tristan K F Shing,Emily C.W. Hung,Tak Yeung Leung,Tze Kin Lau,Rossa W.K. Chiu,Y.M. Dennis Lo +6 more
TL;DR: The existence of placental miRNAs in maternal plasma is demonstrated and some information on their stability and physical nature is provided to open up a new class of molecular markers for pregnancy monitoring.
Journal ArticleDOI
Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: Large scale validity study
Rossa W.K. Chiu,Ranjit Akolekar,Yama W. L. Zheng,Tak Yeung Leung,Hao Sun,K.C. Allen Chan,Fiona M.F. Lun,Attie T. J. I. Go,Elizabeth T. Lau,William W. K. To,W. C. Leung,Rebecca Y. K. Tang,Sidney K. C. Au-Yeung,H. Lam,Yu Y. Kung,Xiuqing Zhang,Xiuqing Zhang,John M.G. van Vugt,Ryoko Minekawa,Mary Hoi Yin Tang,Jun Wang,Cees B.M. Oudejans,Tze K. Lau,Kypros H. Nicolaides,Y.M. Dennis Lo +24 more
TL;DR: Multiplexed maternal plasma DNA sequencing analysis could be used to rule out fetal trisomy 21 among high risk pregnancies and if referrals for amniocentesis or chorionic villus sampling were based on the sequencing test results, about 98% of the invasive diagnostic procedures could be avoided.
Journal ArticleDOI
Molecular Evolution of the SARS Coronavirus, during the Course of the SARS Epidemic in China
Jian Feng He,Guo Wen Peng,Jun Min,De Wen Yu,Wen Jia Liang,Shuyi Zhang,Rui Heng Xu,Huan Ying Zheng,Xin Wei Wu,Jun Xu,Zhan Hui Wang,Ling Fang,Xin Zhang,Hui Li,Xin Ge Yan,Jiahai Lu,Zhihong Hu,Ji Cheng Huang,Zhuo Yue Wan,Jin Lin Hou,Jin Yan Lin,Huai Dong Song,Shengyue Wang,Xiang Jun Zhou,Guo Wei Zhang,Bo Wei Gu,Huajun Zheng,Xiang Lin Zhang,Mei He,Kui Zheng,Bo Fei Wang,Gang Fu,Xiao Ning Wang,Sai Juan Chen,Zhu Chen,Zhu Chen,Pei Hao,Hua Tang,Shuang Xi Ren,Yang Zhong,Zong Ming Guo,Qi Liu,You Gang Miao,Xiangyin Kong,Wei Zhong He,Yixue Li,Chung-I Wu,Guoping Zhao,Rossa W.K. Chiu,Stephen S.C. Chim,Yu K. Tong,Paul K.S. Chan,John S. Tam,Y.M. Dennis Lo +53 more
TL;DR: The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization, and major deletions were observed in the Orf8 region of the genome at the start and the end of the epidemic.