Wilfried Nisch

TL;DR: Examples of MEA biosensor applications are described that have been developed for drug screening and discovery and safety pharmacology in the field of cardiac and neural research and biophysical basics of recording and concepts for analysis of extracellular electrical signals are presented.

TL;DR: This is the first realization of hippocampus cultured organotypically on multi-microelectrode arrays for simultaneous recording and electrical stimulation and this biohybrid system promises to become a powerful tool for drug discovery and for the analysis of neural networks, of synaptic plasticity, and of pathophysiological conditions such as ischemia and epilepsy.

TL;DR: The approach to replace retinal photoreceptors by a subretinally implanted microphotodiode array (MPDA) is summarized and electrophysiological recordings in rabbits and rats are presented which have received such subretinal implants.

TL;DR: The deterioration of the electrical properties of the micro-photodiodes correlated with the morphological damage observed, and strategies aiming at the development of an improved biostable encapsulation of neurotechnological implants have to be investigated.

TL;DR: In this article, a thin film titanium nitride (TiN) microelectrodes were fabricated onto a micro-electrode array by reactive sputtering in a nitrogen/argon atmosphere and showed excellent charge transfer capacity of 40 mC/cm/sup 2/ and low ac-impedance along with high pulse stability.