Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

Aminoalcohol lipidoids and uses thereof

An especially crack-resistant yet elastomeric and pliable polyurethane is provided as a polymer which is especially suitable for medical prostheses, implants, roofing insulators and the like. The polymer is a polycarbonate urethane polymer which is substantially completely devoid of ether linkages.

Crack-resistant polycarbonate urethane polymer prostheses

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

Biodegradable poly (beta-amino esters) and uses thereof

Apparatuses and methods for manipulating droplets on a printed circuit board (PCB) are disclosed. Droplets are actuated upon a printed circuit board substrate surface by the application of electrical potentials to electrodes defined on the PCB. The use of soldermask as an electrode insulator for droplet manipulation as well techniques for adapting other traditional PCB layers and materials for droplet-based microfluidics are also disclosed.

Apparatuses and methods for manipulating droplets on a printed circuit board

A method of producing an article with a color-plus-clear composite coating is described. The method comprises the steps of applying a colored coating composition to a substrate, and applying a clear coating composition over the colored coating composition, wherein the clear coating composition is a curable coating composition comprising: (a) a first component comprising a polymer backbone having appended thereto at least one carbamate functional group, and (b) a second component comprising a compound having a plurality of functional groups that are reactive with said carbamate group.

Composite color-plus-clear coating utilizing carbamate-functional polymer composition in the clearcoat

The present invention relates to heat-curable coating compositions containing A) a prepolymer having an average of 2-4 ketoxime-blocked NCO groups, having an average moleculer weight of 500-15,000 and prepared from aliphatic, cycloaliphatic and aromatic polyisocyanates and one or more polyhydroxy components which contain 0 to 30% by weight of ethylene oxide units and B) a crosslinking agent of the formula ##STR1## wherein R and R 1 represent H or C 1 -C 4 -alkyl, the ratio of equivalents of blocked NCO groups in A) to NH 2 groups in B) being 135:1 to 095:1, characterized in that at least one of the polyhydroxy compounds used for the preparation of the prepolymer contains, in stable dispersion, a polyurethane, a polyurethane-urea and/or a polyurea, which is substantially free from NCO groups, hydroxyl groups and amino groups and which are synthesized from aromatic, aliphatic and/or cycloaliphatic diisocyanates and from diamines, hydrazine and/or diols, provided that at least one of these components carries a radical having hydrophilic characteristics The present invention also relates to the use of these coating compositions in a process for the coating, particularly water vapor-permeable coating, of substrates, preferably textile sheet-like structures and leather

Heat-curable coating compositions

The invention relates to coating compositions comprising (A) a polyurethane based on a polyisocyanate, a diol having an average molecular weight of from 350 to 5000, and a chain lengthening agent having a molecular weight of from 32 to 349, wherein said polyurethane (A) contains ionic groups in a quantity of from 0.1 to 75 milliequivalents per 100 g of polyurethane (A) and more than 6 to 50% by weight, based on polyurethane (A), of polyethylene oxide units (-CH2CH2 0)n- having a sequence length n of from 2 to 50 incorporated into the main chain, and (B) from 30 to 80% by weight, based on the sum of components (A) and (B), of an aqueous phase.

Aqueous coating compositions and their use for the preparation of coatings that are permeable to water vapor

The present disclosure is concerned with solvent free or very low solvent coating compositions suitable for use on flexible sheet form substrates particularly textile substrates. The composition comprises a urethane group-containing prepolymer with OH or CONH 2 terminal groups mixed with a urea or melamine formaldehyde resin and a stable aqueous polymer dispersion or solution. The composition may also contain small amounts of an organic solvent. The coating can be applied to the substrate by direct or reverse coating techniques.

Heat cross linkable polyurethane coating compositions

The present invention is directed to coating compositions (pastes) containing a) about 20 to 90% by weight of an aqueous polyurethane dispersion which has a solids content of about 20 to 60% and wherein the polyurethane is rendered hydrophilic by carboxylate groups, sulphonate groups, pendant polyether chains having oxy-ethylene units, terminal polyether chains having oxyethylene units or mixtures thereof, b) about 0.1 to 5% by weight of a water-soluble, polymeric thickening agent for aqueous polyurethane dispersions which is not a polyurethane and which is free from carboxyl groups, c) about 3 to 80% by weight of water-immiscible organic solvent which is not a solvent for polyurethanes dispersed in water and which has a boiling point up to 250°C, d) about 0.1 to 5% by weight of a cross-linking agent for the polyurethane dispersed in water which does not contain free isocyanate groups and e) about 0.1 to 5% by weight of a hydrophilic polyisocyanate which promotes the adhesion of the coating composition to substrates and is a cross-linking agent for the polyurethane dispersed in water, the sum of the percentages of a) + b) + c) + d) + e) being 100, based on components a) - e). The present invention is also directed to the use of these coating compositions for coating substrates, preferably made of textile or leather, by the direct or transfer process, using the evaporation coagulation technique.

Coating materials containing pur dispersions and solvents and their use for the preparation of water vapor permeable pur coatings

This invention relates to coating compositions based on aqueous polyurethane dispersions, as well as the use of the coating compositions for the production of top coats or finishes on flexible substrates, particularly on PVC. The present coating agents contain an aqueous polyurethane dispersion having certain physico-chemical properties and the following composition of the solid substance: (A) from about 30 to 60%, by weight, of a hexane diol-1,6-polyester diol having a molecular weight of from about 500 to 6000; (B) up to about 8%, by weight, of a relatively low molecular weight triol having a molecular weight of from about 91 to 399; (C) from about 3 to 30%, by weight, of one or more mono- or poly-functional compounds bearing cationic and/or anionic groups and/or containing non-ionic polyoxyethylene segments; (D) from about 20 to 50%, by weight, of a diisocyanate corresponding to the following general formula: ##STR1## wherein R 1 , R 2 and R 3 , which may be the same or different, each represents hydrogen or a straight- or branched-chain aliphatic hydrocarbon radical containing from 1 to 4 carbon atoms; (E) from about 2.5 to 20%, by weight, of other aliphatic and/or cycloaliphatic diisocyanates; and (F) from about 0.5 to 4%, by weight, of hydrazine; and optionally conventional additives, auxiliaries and catalysts.

Wilhelm Dr Thoma

Papers

Heat-curable coating compositions

Aqueous coating compositions and their use for the preparation of coatings that are permeable to water vapor

Heat cross linkable polyurethane coating compositions

Coating materials containing pur dispersions and solvents and their use for the preparation of water vapor permeable pur coatings

Coating agents of polyurethane dispersions and the use thereof for top coats and finishes