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Willem G. Linscheer

Researcher at United States Department of Veterans Affairs

Publications -  18
Citations -  245

Willem G. Linscheer is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Acetaminophen & Propylthiouracil. The author has an hindex of 8, co-authored 18 publications receiving 243 citations. Previous affiliations of Willem G. Linscheer include Syracuse University & State University of New York System.

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Sarcoidlike granulomas as an early manifestation of Whipple's disease.

TL;DR: It is suggested that sarcoidlike tissue reaction can be an early manifestation of Whipple's disease, recognition of which may have practical value in facilitating an early diagnosis and treatment.
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Mechanism of the protective effect of propylthiouracil against acetaminophen (Tylenol) toxicity in the rat.

TL;DR: The mechanism of the protective effect of induced HT on hepatic toxicity of AAP was attributed to induction of increased hepatic GSH levels resulting in decreased covalentbinding of a toxic metabolite of AAP, and enhanced glucuronidation may prevent either formation or binding of a reactive metabolite to hepatocytes, and prevention of inflammatory reaction to necrotic liver tissue.
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Hepatotoxicity and metabolism of acetaminophen in male and female rats.

TL;DR: Ovariectomy of female rats tended to increase susceptibility to hepatotoxicity in comparison to their respective controls, and aside from the reported sex differences in the cytochrome P-450-dependent MFO enzymes, there are significant differences in GSH utilization.
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Lecithin Supplementation in Healthy Volunteers Effect on Cholesterol Esterification and Plasma, and Bile lipids

TL;DR: In vitro cholesterol esterification was found linearly related to plasma-free cholesterol, and the molar percent of bile acids, TC and TPL as well as the lithogenic index in both hepatic and gallbladder bile were also unaltered by 4 weeks of lecithin supplementation.
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Impaired absorption of micellar long-chain fatty acid in patients with alcoholic cirrhosis.

TL;DR: Impaired mucosal transport of long-chain fatty acid in patients with liver cirrhosis contributes to fat malabsorption and malnutrition in these patients, and it is suggested that this abnormality is related to portal or lymphatic hypertension.