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William B. Martens
Researcher at University of Rochester Medical Center
Publications - 59
Citations - 2396
William B. Martens is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Myotonic dystrophy & Medicine. The author has an hindex of 24, co-authored 49 publications receiving 1800 citations. Previous affiliations of William B. Martens include Nemours Foundation & St. John Fisher College.
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Journal ArticleDOI
Observational study of spinal muscular atrophy type I and implications for clinical trials
Richard S. Finkel,Michael P. McDermott,Petra Kaufmann,Basil T. Darras,Wendy K. Chung,Douglas M. Sproule,Peter B. Kang,A. Reghan Foley,Michelle L. Yang,William B. Martens,Maryam Oskoui,Allan M. Glanzman,Jean Flickinger,Jacqueline Montes,Sally Dunaway,Jessica O'Hagen,Janet Quigley,Susan Riley,Maryjane Benton,Patricia A. Ryan,Megan Montgomery,Jonathan Marra,Clifton L. Gooch,Darryl C. De Vivo +23 more
TL;DR: Infants with SMA-I can be effectively enrolled and retained in a 12-month natural history study until a majority reach the combined endpoint of death, and these outcome data can be used for clinical trial design.
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An expanded version of the Hammersmith Functional Motor Scale for SMA II and III patients.
Jessica O'Hagen,Allan M. Glanzman,Michael P. McDermott,Patricia A. Ryan,Jean Flickinger,Janet Quigley,Susan Riley,Erica Sanborn,Carrie Irvine,William B. Martens,Christine Annis,Rabi Tawil,Maryam Oskoui,Basil T. Darras,Basil T. Darras,Richard S. Finkel,Richard S. Finkel,Darryl C. De Vivo +17 more
TL;DR: The expanded Hammersmith Functional Motor Scale allows assessment of high functioning SMA type II and III patients and justification with established motor function measures justify use in future SMA clinical trials.
Journal ArticleDOI
Prospective cohort study of spinal muscular atrophy types 2 and 3
Petra Kaufmann,Michael P. McDermott,Basil T. Darras,Richard S. Finkel,Douglas M. Sproule,Peter B. Kang,Maryam Oskoui,Andrei Constantinescu,Clifton L. Gooch,A. Reghan Foley,Michele L. Yang,Rabi Tawil,Wendy K. Chung,William B. Martens,Jacqueline Montes,Vanessa Battista,Jessica O'Hagen,Sally Dunaway,Jean Flickinger,Janet Quigley,Susan Riley,Allan M. Glanzman,Maryjane Benton,Patricia A. Ryan,Mark Punyanitya,Megan Montgomery,Jonathan Marra,Benjamin Koo,Darryl C. De Vivo +28 more
TL;DR: The intermediate and mild phenotypes of SMA show slow functional declines when observation periods exceed 1 year, and whole body muscle mass, hand muscle compound motor action potentials, and muscle strength are associated with clinical measures of motor function.
Journal ArticleDOI
Patient-reported impact of symptoms in myotonic dystrophy type 1 (PRISM-1)
Chad Heatwole,Rita K. Bode,Nicholas E. Johnson,Christine Quinn,William B. Martens,Michael P. McDermott,Nan E. Rothrock,Charles A. Thornton,Barbara G. Vickrey,David Victorson,Richard T. Moxley +10 more
TL;DR: There are a wide range of symptoms that significantly affect the lives of patients with DM1 and these symptoms, some previously underrecognized, have varying levels of importance in the DM1 population and are nonlinearly dependent on patient age and CTG repeat length.
Journal ArticleDOI
Validation of the Expanded Hammersmith Functional Motor Scale in Spinal Muscular Atrophy Type II and III
Allan M. Glanzman,Jessica O'Hagen,Michael P. McDermott,William B. Martens,Jean Flickinger,Susan Riley,Janet Quigley,Jacqueline Montes,Sally Dunaway,Liyong Deng,Liyong Deng,Wendy K. Chung,Rabi Tawil,Basil T. Darras,Basil T. Darras,Darryl C. De Vivo,Petra Kaufmann,Richard S. Finkel,Richard S. Finkel +18 more
TL;DR: The Expanded Hammersmith Functional Motor Scale demonstrates significant associations with established measures of function, strength, and genotype, and discriminates patients based on function, diagnostic category, and bi-level positive airway pressure need.