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William C. Stevens
Researcher at University of Minnesota
Publications - 10
Citations - 734
William C. Stevens is an academic researcher from University of Minnesota. The author has contributed to research in topics: Cancer & Behavioural despair test. The author has an hindex of 4, co-authored 10 publications receiving 702 citations.
Papers
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Journal ArticleDOI
Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats
Stephen D. Mague,Andrea M. Pliakas,Mark S. Todtenkopf,Hilarie C. Tomasiewicz,Yan Zhang,William C. Stevens,Robert M. Jones,Philip S. Portoghese,William A. Carlezon,William A. Carlezon +9 more
TL;DR: Findings are consistent with the hypothesis that CREB-mediated induction of dynorphin in the NAc “triggers” immobility behavior in the FST and raise the possibility that κ-antagonists may have efficacy as antidepressants, but lack stimulant or reward-related effects.
Journal ArticleDOI
Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha.
Brett B. Busch,William C. Stevens,Richard J. Martin,Peter Ordentlich,Sihong Zhou,Douglas W. Sapp,Robert A. Horlick,Raju Mohan +7 more
TL;DR: The discovery of the first potent and selective inverse agonist of ERR alpha is described, which will elucidate the endocrine signaling pathways mediated by ERRalpha including association with human disease states.
Journal ArticleDOI
Potent and Selective Indolomorphinan Antagonists of the Kappa-Opioid Receptor
William C. Stevens,Robert M. Jones,Govindan Subramanian,Thomas G. Metzger,David M. Ferguson,Philip S. Portoghese +5 more
TL;DR: It was concluded that the basis for the high kappa selectivity of GNTI is related both to association with the nonconserved Glu297 residue and to unfavorable interactions with an equivalent position in mu- and delta-opioid receptors.
Patent
3-phenyl-n- ((1, 3, 4) thiadiazol-2-yl) -acrylamide derivatives and related compounds as modulators of estrogen-related receptors for the treatment of e.g. cancer, rheumatoid arthritis or neurological disorders
TL;DR: In this paper, compounds of formula (I) for modulating the activity of the estrogen-related receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder related to the activation of the ERRα were described.
Patent
Pyrrolderivate als pharmazeutische wirkstoffe
Bannen Lynne Canne,Jeff Chen,Lisa Esther Dalrymple,Brenton T. Flatt,Timothy Patrick Forsyth,Xiao-Hu Gu,Morrison B. Mac,Larry W. Mann,Grace Mann,Richard Martin,Raju Mohan,Brett Murphy,Michael Charles Nyman,William C. Stevens,Tie-Lin Wang,Yong Wang,Wu Jason H +16 more