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William A. Carlezon
Researcher at Harvard University
Publications - 237
Citations - 21364
William A. Carlezon is an academic researcher from Harvard University. The author has contributed to research in topics: Nucleus accumbens & κ-opioid receptor. The author has an hindex of 69, co-authored 221 publications receiving 19565 citations. Previous affiliations of William A. Carlezon include Yale University & University of Minnesota.
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Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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The many faces of CREB
TL;DR: Emerging evidence suggests that strategies that exploit regional differences in upstream factors or that target specific CREB-regulated genes, rather than CREB itself, could make a promising contribution to the treatment of neuropsychiatric conditions.
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Regulation of Cocaine Reward by CREB
William A. Carlezon,Johannes Thome,Valerie G. Olson,Sarah B. Lane-Ladd,Edward S. Brodkin,Noboru Hiroi,Ronald S. Duman,Rachael L. Neve,Eric J. Nestler +8 more
TL;DR: An intracellular cascade-culminating in gene expression-through which exposure to cocaine modifies subsequent responsiveness to the drug is identified.
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Mania-like behavior induced by disruption of CLOCK.
Kole T. Roybal,David Theobold,Ami Graham,Jennifer A. DiNieri,Scott J. Russo,Vaishnav Krishnan,Sumana Chakravarty,Joseph Peevey,Nathan Oehrlein,Shari G. Birnbaum,Martha Hotz Vitaterna,Paul Orsulak,Joseph S. Takahashi,Eric J. Nestler,William A. Carlezon,Colleen A. McClung +15 more
TL;DR: It is shown that mice carrying a mutation in the Clock gene display an overall behavioral profile that is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower anxiety, and an increase in the reward value for cocaine, sucrose, and medial forebrain bundle stimulation.
Journal ArticleDOI
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Max B. Kelz,Jingshan Chen,William A. Carlezon,William A. Carlezon,Kim Whisler,Lauren Gilden,Alison M. Beckmann,Cathy Steffen,Ya-Jun Zhang,Louis A. Marotti,David W. Self,Tatiana Tkatch,Gytis Baranauskas,D. James Surmeier,Rachael L. Neve,Ronald S. Duman,Marina R. Picciotto,Eric J. Nestler +17 more
TL;DR: It is shown that ΔFosB expression increases the responsiveness of an animal to the rewarding and locomotor-activating effects of cocaine, which supports a model in which Δ FosB, by altering gene expression, enhances sensitivity to cocaine and may thereby contribute to cocaine addiction.