William E. Boden

TL;DR: Unstable angina and non–ST-segment elevation myocardial infarction (NSTEMI) comprise a growing percentage of patients with acute coronary syndromes (ACS) and are emerging as a major public health problem worldwide, especially in Western countries, despite significant improvements and refinements.

TL;DR: It is concluded that tailoring the early initial therapy in hospital to the level of risk is essential to optimizing efficacy and clinical outcomes in this challenging, but common group of ACS patients.

TL;DR: In this article, percutaneous coronary intervention did not reduce the incidence of death, myocardial infarction, or other major cardiovascular events when added to optimal medical therapy.

TL;DR: The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches trial demonstrated no overall difference in the composite primary endpoint and the secondary endpoints of cardiovascular (CV) death/myocardial infarction or all-cause mortality between an initial invasive or conservative strategy among participants with chronic coronary disease and moderate or severe myocardial ischemia as discussed by the authors .

TL;DR: In this article , a post hoc analysis of ISCHEMIA participants was conducted to identify markers of LMD as detected on coronary computed tomography angiography (CTA), using clinical and stress testing parameters.