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William E. Sonntag
Researcher at University of Oklahoma Health Sciences Center
Publications - 273
Citations - 16761
William E. Sonntag is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Hippocampal formation & Cognitive decline. The author has an hindex of 72, co-authored 265 publications receiving 15103 citations. Previous affiliations of William E. Sonntag include Michigan State University & University of Oklahoma.
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Mechanisms of vascular aging: new perspectives.
TL;DR: Practical interventions for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the effects of anti-inflammatory treatments, regular exercise, dietary interventions, and caloric restriction mimetics.
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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.
Zoltan Ungvari,Zsolt Bagi,Attila Feher,Fabio A. Recchia,William E. Sonntag,Kevin J. Pearson,Rafael de Cabo,Anna Csiszar +7 more
TL;DR: It is found that in cultured coronary arterial endothelial cells, resveratrol, in a dose-dependent manner, significantly increases transcriptional activity of Nrf2 and confers endothelial protective effects which are mediated by the activation of NRF2.
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Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
Robin J. Lichtenwalner,M.E Forbes,S. A. Bennett,Colleen D. Lynch,William E. Sonntag,David R. Riddle +5 more
TL;DR: It is suggested that IGF-I may be an important regulator of neurogenesis in the adult and aging hippocampus and that an age-related decline in IGF- I-dependent neuroGenesis could contribute to age- related cognitive changes.
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Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1.
TL;DR: It is concluded that GH and IGF-1 have an important role in the decline in vascular density with age and it is suggested that decreases in vasculardensity may have important implications for the age-related decline in cerebral blood flow and brain function.
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Decreased pulsatile release of growth hormone in old male rats.
TL;DR: It is demonstrated that GH secretion is depressed in old male rats, and this is associated with diminished pulsatile release of GH, and a relationship exists among the reduction in somatostatin content, pituitary GH content, and attenuated GH secretion in oldmale rats.