William F. Goins

TL;DR: A new platform technology for visualizing transgene expression in living subjects using magnetic resonance imaging (MRI) using a vector, where the cells construct the MRI contrast agent in situ using genetic instructions introduced by the vector, thereby simplifying intracellular delivery.

TL;DR: DNA sequence analysis of the upstream regulatory region of IE region 1 detected two distinct repeats of 19 and 18 nucleotides, both being repeated four times, suggesting a putative cruciform structure could form through the surrounding sequences with each 18-nucleotide repeat being located in the unpaired region.

TL;DR: Viral mutants deleted simultaneously for the IE genes encoding ICP4, ICP22 and ICP27 showed substantially reduced cytotoxicity and may prove useful for efficient gene transfer and extended transgene expression in neurons in vitro and in vivo.

TL;DR: The results demonstrate that the function of sensory neurons can be selectively altered by viral delivery of a transgene, and may be useful for treatment of chronic pain and hyperalgesia in humans.

TL;DR: The promising gene therapy strategies that have the potential to treat patients with neurological diseases are described and prospects for future development of gene therapy are discussed.