William G. Taylor

TL;DR: The release of this growth factor by human embryonic fibroblasts raises the possibility that KGF may play a role in mesenchymal stimulation of normal epithelial cell proliferation, and Lack of mitogenic activity on either fibro Blasts or endothelial cells indicated that K GF possessed a target cell specificity distinct from any previously characterized growth factor.

TL;DR: Its site of synthesis and spectrum of targets imply that this growth factor may play an important role as a paracrine mediator of the proliferation of melanocytes and endothelial cells, as well as cells of epithelial origin.

TL;DR: In this paper, a mammalian recombinant expression system that yields ∼3 mg of purified protein/liter of conditioned medium was developed to facilitate the biochemical and biological analysis of sFRP-1.

TL;DR: Functional assays in organ culture and in vivo and studies of KGF regulation by sex sterorid hormones reinforced the idea that KGF acts predominantly on epithelial cells to elicit a variety of responses including proliferation, migration and morphogenesis.

TL;DR: In Wnt-overexpressing PC12 cells, dominant-negative Akt decreased free β-catenin and derepressed nerve growth factor-induced differentiation, and acts in association with Dvl as an important regulator of the Wnt signaling pathway.