M
Matthew D. Layne
Researcher at Boston University
Publications - 86
Citations - 5799
Matthew D. Layne is an academic researcher from Boston University. The author has contributed to research in topics: Vascular smooth muscle & Adipose tissue. The author has an hindex of 38, co-authored 81 publications receiving 5414 citations. Previous affiliations of Matthew D. Layne include Children's Hospital of Philadelphia & Harvard University.
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Journal ArticleDOI
Cardiac-Specific Expression of Heme Oxygenase-1 Protects Against Ischemia and Reperfusion Injury in Transgenic Mice
Shaw-Fang Yet,Rong Tian,Matthew D. Layne,Zhi Yuan Wang,Koji Maemura,Maria Solovyeva,Bonna Ith,Luis G. Melo,Lunan Zhang,Joanne S. Ingwall,Victor J. Dzau,Mu-En Lee,Mark A. Perrella +12 more
TL;DR: It is demonstrated that overexpression of HO-1 in the cardiomyocyte protects against ischemia and reperfusion injury, thus improving the recovery of cardiac function.
Journal ArticleDOI
Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice.
Shaw-Fang Yet,Mark A. Perrella,Matthew D. Layne,Chung-Ming Hsieh,Koji Maemura,Lester Kobzik,Philippe Wiesel,Helen Christou,Stella Kourembanas,Mu-En Lee +9 more
TL;DR: The data suggest that in the absence of HO-1, cardiomyocytes have a maladaptive response to hypoxia and subsequent pulmonary hypertension.
Journal ArticleDOI
Akt participation in the Wnt signaling pathway through Dishevelled.
Shinya Fukumoto,Chung-Ming Hsieh,Koji Maemura,Matthew D. Layne,Shaw-Fang Yet,Kyung-Han Lee,Takashi Matsui,Anthony Rosenzweig,William G. Taylor,Jeffrey S. Rubin,Mark A. Perrella,Mu-En Lee +11 more
TL;DR: In Wnt-overexpressing PC12 cells, dominant-negative Akt decreased free β-catenin and derepressed nerve growth factor-induced differentiation, and acts in association with Dvl as an important regulator of the Wnt signaling pathway.
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Gene Therapy Strategy for Long-Term Myocardial Protection Using Adeno-Associated Virus-Mediated Delivery of Heme Oxygenase Gene
Luis G. Melo,Reitu Agrawal,Lunan Zhang,Mojgan Rezvani,Abeel A. Mangi,Afshin Ehsan,Daniel P. Griese,Giorgio Dell'Acqua,Michael J. Mann,Jun-ichi Oyama,Shaw-Fang Yet,Matthew D. Layne,Mark A. Perrella,Victor J. Dzau +13 more
TL;DR: The data suggest that this novel “pre-event” gene transfer approach may provide sustained tissue protection from future repeated episodes of injury and may be beneficial as preventive therapy for patients with or at risk of developing coronary ischemic events.
Journal ArticleDOI
Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling
Shaw-Fang Yet,Matthew D. Layne,Xiaoli Liu,Yen-Hsu Chen,Yen-Hsu Chen,Bonna Ith,Nicholas E.S. Sibinga,Mark A. Perrella +7 more
TL;DR: The data demonstrate that HO‐1 plays an essential protective role in the pathophysiology of atherosclerosis and vein graft stenosis.