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William G. Willmore

Researcher at Carleton University

Publications -  99
Citations -  4042

William G. Willmore is an academic researcher from Carleton University. The author has contributed to research in topics: Oxidative stress & Gene expression. The author has an hindex of 28, co-authored 92 publications receiving 3256 citations. Previous affiliations of William G. Willmore include University of Ottawa & Brigham and Women's Hospital.

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Quantification of lipid peroxidation in tissue extracts based on Fe(III)xylenol orange complex formation

TL;DR: Results indicate that the formation of the Fe(III)xylenol orange complex reflects a chemical amplification of the original level of lipid hydroperoxides present in tissue extracts and that peroxidizable lipids do not influence the assay.
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Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling.

TL;DR: The mechanism by which two heme-binding ligands, carbon monoxide and nitric oxide, affect oxygen sensing and signaling is investigated, presumably as heme ligands binding to the oxygen sensor, whereas desferrioxamine and perhaps cobalt appear to act at a site downstream.
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Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions

TL;DR: This work provides the first comprehensive review on how redox signals mediated through cysteine oxidation, namely S-oxidation, S-glutathionylation, and S-nitrosylation, regulate key mitochondrial functions including nutrient oxidation, oxidative phosphorylation, ROS production, mitochondrial permeability transition (MPT), apoptosis, and mitochondrial fission and fusion.
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A comparative and evolutionary approach to oxidative stress in fish: A review

TL;DR: It is demonstrated that oxidative stress plays a key role in shaping fish's responses to environmental change as well as life history strategies, and how emerging threats affect oxidative stress parameters in fish is described.
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Antioxidant systems and anoxia tolerance in a freshwater turtle Trachemys scripta elegans.

TL;DR: The results show that biochemical adaptation for natural anoxia tolerance in turtles includes well-developed antioxidant defenses that minimize or prevent damage by reactive oxygen species during the reoxygenation of organs after anoxic submergence.