H
H. Franklin Bunn
Researcher at Brigham and Women's Hospital
Publications - 95
Citations - 8015
H. Franklin Bunn is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Hemoglobin & Erythropoietin. The author has an hindex of 40, co-authored 94 publications receiving 7681 citations. Previous affiliations of H. Franklin Bunn include Harvard University & Johns Hopkins University School of Medicine.
Papers
More filters
Journal ArticleDOI
Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit
TL;DR: Results suggest that an intact redox-dependent signaling pathway is required for destablization of the HIF-1α protein, which was rapidly and drastically decreased in vivo following an abrupt increase to normal oxygen tension.
Journal ArticleDOI
An essential role for p300/CBP in the cellular response to hypoxia
Zoltan Arany,L. Eric Huang,Richard Eckner,Shoumo Bhattacharya,C. H. Jiang,M A Goldberg,H. Franklin Bunn,David M. Livingston +7 more
TL;DR: In this article, the intact cDNA for HIF-1α and p300/CBP were cloned and shown to participate in the induction of hypoxia-responsive genes, including vascular endothelial growth factor.
Journal ArticleDOI
Further identification of the nature and linkage of the carbohydrate in hemoglobin A1c.
TL;DR: It is found that Hb A1c contains neutral sugars which are only partially hydrolyzed from the N-termini of β chains, and it is proposed that in the red cell, glucose binds to the α-amino position of hemoglobin β-chains (valine) in an aldimine (Schiff base) linkage.
Journal ArticleDOI
Regulation of the erythropoietin gene.
TL;DR: Erythropoietin (Epo), the hormone that stimulates red blood cell production, is induced by hypoxia and the human hepatoma cell line, Hep3B, is utilized to investigate the regulation of the Epo gene.
Journal ArticleDOI
Hypoxia-inducible factor and its biomedical relevance.
L. Eric Huang,H. Franklin Bunn +1 more
TL;DR: This Minireview summarizes a large body of recent information on the oxygen-dependent regulation of the subunit of HIF, by both ubiquitin-proteasomal degradation and by transcriptional activation.