W
William Hiesinger
Researcher at Stanford University
Publications - 103
Citations - 1952
William Hiesinger is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Ventricular assist device. The author has an hindex of 19, co-authored 84 publications receiving 1367 citations. Previous affiliations of William Hiesinger include University of Pennsylvania & Hospital of the University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
Early planned institution of biventricular mechanical circulatory support results in improved outcomes compared with delayed conversion of a left ventricular assist device to a biventricular assist device
J. Raymond Fitzpatrick,John R. Frederick,William Hiesinger,Vivian M. Hsu,Ryan C. McCormick,Elliott D. Kozin,Carine M. Laporte,Mary Lou O’Hara,Elan Howell,Deborah Dougherty,Jeffrey E. Cohen,Kevin W. Southerland,Jessica L. Howard,E. Carter Paulson,Michael A. Acker,Rohinton J. Morris,Y. Joseph Woo +16 more
TL;DR: When patients at high risk for failure of isolated left ventricular assist device support are identified, proceeding directly to biventricular assist device implantation is advised because early institution of bivocentular support results in dramatic improvement in survival.
Journal ArticleDOI
Predicting right ventricular failure in the modern, continuous flow left ventricular assist device era.
Pavan Atluri,Andrew B. Goldstone,Alex Fairman,John W. MacArthur,Yasuhiro Shudo,Jeffrey E. Cohen,Alexandra L. Acker,William Hiesinger,Jessica L. Howard,Michael A. Acker,Y. Joseph Woo +10 more
TL;DR: A highly sensitive and easy to use risk score for determining RV failure was generated that outperformed other established risk stratification tools.
Journal ArticleDOI
Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression.
Pavan Atluri,Kevin J. Morine,George P. Liao,Corinna M. Panlilio,Mark F. Berry,Vivian M. Hsu,William Hiesinger,Jeffrey E. Cohen,Y. Joseph Woo +8 more
TL;DR: Total myocardial apelin and APJ receptor levels increase in compensation for ischemic cardiomyopathy, as demonstrated by western blot and enzyme immunoassay analysis.
Journal ArticleDOI
Single-Cell Transcriptomic Profiling of Vascular Smooth Muscle Cell Phenotype Modulation in Marfan Syndrome Aortic Aneurysm.
Albert J. Pedroza,Yasushi Tashima,Rohan Shad,Paul Cheng,Robert C. Wirka,Samantha Churovich,Ken Nakamura,Nobu Yokoyama,Jason Z. Cui,Cristiana Iosef,William Hiesinger,Thomas Quertermous,Michael P. Fischbein +12 more
TL;DR: The disease-specific signature of modSMCs is characterized and temporal, transcriptomic context to the current understanding of the role TGF-β plays in MFS aortopathy is provided and single-cell RNA sequencing implicates T GF-β signaling and Klf4 overexpression as potential upstream drivers of SMC modulation.
Journal ArticleDOI
Stromal Cell-Derived Factor-1α Activation of Tissue-Engineered Endothelial Progenitor Cell Matrix Enhances Ventricular Function After Myocardial Infarction by Inducing Neovasculogenesis
John R. Frederick,J. Raymond Fitzpatrick,Ryan C. McCormick,David A. Harris,Ah-Young Kim,Jeffrey R. Muenzer,Nicole A. Marotta,Maximilian J. Smith,Jeffrey E. Cohen,William Hiesinger,Pavan Atluri,Y. Joseph Woo +11 more
TL;DR: It is hypothesized that implantation of a tissue-engineered extracellular matrix (ECM) scaffold seeded with EPCs primed with SDF could induce borderzone neovasculogenesis, prevent adverse geometric remodeling, and preserve ventricular function after myocardial infarction.