W
William N. Washburn
Researcher at Bristol-Myers Squibb
Publications - 69
Citations - 3160
William N. Washburn is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Diabetes mellitus & Dapagliflozin. The author has an hindex of 23, co-authored 69 publications receiving 2994 citations.
Papers
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Journal ArticleDOI
BMS-196085: A potent and selective full agonist of the human β3 adrenergic receptor
A.V. Gavai,Philip M. Sher,Amarendra B. Mikkilineni,Poss Kathleen M,P.J. McCann,Ravindar N. Girotra,Liesl G. Fisher,Ginger Wu,Mark S. Bednarz,Arvind Mathur,Tammy C. Wang,Chongqing Sun,Dorothy Slusarchyk,S. Skwish,G.T. Allen,D.E. Hillyer,B.H. Frohlich,B.E. Abboa-Offei,Michael Cap,T.L. Waldron,R.J. George,Belay Tesfamariam,T.W. Harper,Carl P. Ciosek,D.A. Young,Kenneth E.J. Dickinson,A A Seymour,C.M. Arbeeny,William N. Washburn +28 more
TL;DR: A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity, and BMS-196085 was chosen for clinical evaluation on the basis of its desirable in vitro and in vivo properties.
Journal ArticleDOI
Cacao consumption during the 8th century at Alkali Ridge, southeastern Utah
TL;DR: Theobroma cacao was detected in the ceramic assemblage at the 8th century Site 13, Alkali Ridge, southeastern Utah as mentioned in this paper, and the presence of this Mesoamerican beverage during the Pueblo I period is the earliest reported use of cacao in the northern American Southwest.
Journal ArticleDOI
BMS-201620: a selective beta 3 agonist.
William N. Washburn,Chongqing Sun,G. S. Bisacchi,Ginger Wu,Peter T. W. Cheng,Philip M. Sher,Denis E. Ryono,A.V. Gavai,Poss Kathleen M,Ravindar N. Girotra,P.J. McCann,Amarendra B. Mikkilineni,Tamara Dejneka,Tammy C. Wang,Z. Merchant,M. Morella,C.M. Arbeeny,T.W. Harper,Dorothy Slusarchyk,S. Skwish,Anita D. Russell,G.T. Allen,Belay Tesfamariam,B.H. Frohlich,B.E. Abboa-Offei,Michael Cap,T.L. Waldron,R.J. George,D.A. Young,Kenneth E.J. Dickinson,A A Seymour +30 more
TL;DR: A series of N-(4-hydroxy-3-methylsulfonanilidoethanol)arylglycinamides were prepared and evaluated for their human beta3 adrenergic receptor agonist activity, leading to the identification of BMS-201620, a potent beta3 full agonist.
Journal ArticleDOI
Diastereoselective oxidation of sulfides to sulfoxides. Synthesis of novel C-6 sulfoxy tetrahydromevinic acids
Poss Kathleen M,Sam T. Chao,Eric M. Gordon,P.J. McCann,Dinos Santafianos,Sarah C. Traeger,Varma Ravi K,William N. Washburn +7 more
TL;DR: In this article, the synthesis and diastereoselective oxidation of novel tetrahydromevinic acid lactone sulfides to sulfoxides was described, and the synthesis of tetrahedronic acid is described.
Patent
2-amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
TL;DR: In this paper, the authors have provided novel compounds which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring GPCI therapy such as diabetes and related conditions.