W
William R. Shapiro
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 42
Citations - 2028
William R. Shapiro is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Glioma & Brain tumor. The author has an hindex of 22, co-authored 38 publications receiving 1995 citations. Previous affiliations of William R. Shapiro include St. Joseph's Hospital and Medical Center.
Papers
More filters
Journal ArticleDOI
Randomized trial of three chemotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma
William R. Shapiro,S. B. Green,P. C. Burger,Mahaley Ms,Selker Rg,VanGilder Jc,Robertson Jt,J. Ransohoff,J. Mealey,Strike Ta +9 more
TL;DR: Within 3 weeks of definitive surgery, 571 adult patients with histologically confirmed, supratentorial malignant gliomas were randomly assigned to receive one of three chemotherapy regimens: BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) alone,BCNU plus hydroxyurea alternating with procarbazine plus VM-26 (epipodophyllotoxin).
Journal Article
Treatment of meningeal neoplasms.
Journal ArticleDOI
Treatment of neuroectodermal brain tumors
TL;DR: Prospective clinical trials support the view that malignant neuroectodermal tumors should be treated vigorously using a multimodal approach that includes surgical resection, high‐dose radiation therapy, and prolonged maintenance chemotherapy.
Journal ArticleDOI
Opening the blood-brain and blood-tumor barriers in experimental rat brain tumors: the effect of intracarotid hyperosmolar mannitol on capillary permeability and blood flow.
E. M. Hiesiger,R. M. Voorhies,George A. Basler,L. E. Lipschutz,Jerome B. Posner,William R. Shapiro +5 more
TL;DR: The net effect of the mannitol was to reverse the tumor‐to‐cortex permeability relationship, and data provide little justification for using intracarotidMannitol during chemotherapy of human brain tumors.
Journal ArticleDOI
Experimental spinal cord compression by epidural neoplasms.
TL;DR: Both spinal cord edema and clinical symptoms are lessened by treating symptomatic animals with dexamethasone and evidence for vasogenic edema in spinal cord compressed by tumor includes increased water content, leakage of horseradish peroxidase into gray matter, and histologic evidence of edema.