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William R. Welch
Researcher at Brigham and Women's Hospital
Publications - 159
Citations - 16485
William R. Welch is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Ovarian cancer & Serous fluid. The author has an hindex of 58, co-authored 159 publications receiving 15798 citations. Previous affiliations of William R. Welch include Memorial Hospital of South Bend & Duke University.
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Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
TL;DR: The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).
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Determinants of Ovarian Cancer Risk. II. Inferences Regarding Pathogenesis
TL;DR: Entrapment of surface epithelium within the ovarian stroma was proposed as an initial event in the pathogenesis of cystadenocarcinoma of the ovary and animal experiments suggested that gonadotropin excess and stromal stimulation may result by disturbing normal feedback inhibition between ovarian and pituitary or by destroying ovarian follicles.
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Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125.
Salim E. Kabawat,Robert C. Bast,Atul K. Bhan,William R. Welch,Robert C. Knapp,Robert B. Colvin +5 more
TL;DR: Apparently, this antigen disappears early in the course of formation of the ovarian epithelium and is reexpressed in certain reactive and neoplastic lesions, a process that could be termed “molecular metaplasia.”
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Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas.
Ronny Drapkin,Hans Henning von Horsten,Yafang Lin,Samuel C. Mok,Christopher P. Crum,William R. Welch,Jonathan L. Hecht +6 more
TL;DR: Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types of EOCs.
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Ovarian sex cord tumor with annular tubules. Review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix†
TL;DR: Of the 74 cases that form the basis of this investigation, 27 were associated with the Peutz‐Jeghers syndrome; these tumors were all benign and were typically multifocal, bilateral, very small or even microscopical in size and calcified.