[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Pedagosko i psiholosko testiranje i procjenjivanje spadaju među najvažnije doprinose znanosti o ponasanju nasem drustvu i pružaju temeljna i znacajna poboljsanja u odnosu na ranije postupke. Iako se ne može ustvrditi da su svi testovi dovoljno usavrseni niti da su sva testiranja razborita i korisna, postoji velika kolicina informacija koje ukazuju na ucinkovitost kvalitetnih instrumenata u onim situacijama u kojima je njihovo koristenje potkrijepljeno validacijskim podacima. Pravilna upotreba testova može dovesti do boljih odluka o pojedincima i programima nego sto bi to bio slucaj bez njihovog koristenja, a također i ukazati na put za siri i pravedniji pristup obrazovanju i zaposljavanju. Međutim, losa upotreba testova može dovesti do zamjetne stete nanesene ispitanicima i drugim sudionicima u procesu donosenja odluka na temelju testovnih podataka. Cilj Standarda je promoviranje kvalitetne i eticne upotrebe testova te uspostavljanje osnovice za ocjenu kvalitete postupaka testiranja. Svrha objavljivanja Standarda je uspostavljanje kriterija za evaluaciju testova, provedbe testiranja i posljedica upotrebe testova. Iako bi evaluacija prikladnosti testa ili njegove primjene trebala ovisiti prvenstveno o strucnim misljenjima, Standardi pružaju okvir koji osigurava obuhvacanje svih relevantnih pitanja. Bilo bi poželjno da svi autori, sponzori, nakladnici i korisnici profesionalnih testova usvoje Standarde te da poticu druge da ih također prihvate.

Standards for educational and psychological testing

https://www.medpagetoday.com/upload/2008/3/6/CRC.pdf

Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.

The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed. Starting from well-known basic concepts, and drawing on examples from biology and biomedicine, the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed. The way these properties are controlled and used is illustrated with reference to (i) magnetic separation of labelled cells and other biological entities; (ii) therapeutic drug, gene and radionuclide delivery; (iii) radio frequency methods for the catabolism of tumours via hyperthermia; and (iv) contrast enhancement agents for magnetic resonance imaging applications. Future prospects are also discussed.

https://iopscience.iop.org/article/10.1088/0022-3727/36/13/201/pdf

Applications of magnetic nanoparticles in biomedicine

Bevacizumab plus Irinotecan,Fluorouracil,and Leucovorin for Metastatic Colorectal Cancer

We describe a case of a patient who presented with recurrent abdominal pain due to small bowel angioedema believed to be caused by a recently started ACE inhibitor with classic imaging features. Very few cases of visceral angioedema due to ACE inhibitor use are described in the literature. This case demonstrates a unique direct causal association between the onset of drug administration and symptomatic bowel angioedema as well as ascites, spontaneous resolution on stopping ACE inhibitor, and recurrence of acute clinical symptoms and imaging features on resumption of the drug.

https://www.omicsonline.org/open-access/angiotensin-converting-enzyme-ace-inhibitor-associated-small-bowelangioedema-and-ascites-presenting-as-recurrent-acute-abdomen-a-c-2161-069X-1000464.pdf

Angiotensin Converting Enzyme (ACE) Inhibitor Associated Small BowelAngioedema and Ascites Presenting as Recurrent Acute Abdomen: A CaseReport

In Reply to Drs. Hannoun-Levi and Raoust

<h3>Objectives</h3> Adjuvant vaginal cuff brachytherapy (VCB) improves vaginal control rates in early stage endometrial cancer. We propose a shorter course of VCB would be non-inferior in safety, efficacy and quality of life metrics compared to standard course VCB. <h3>Methods</h3> This multi-institutional trial randomized early stage endometrial patients to adjuvant short course VCB (11 Gy x 2 fractions to the surface delivered a week apart) or the standard of care VCB (either 6 Gy x 5 fractions to the surface, 7 Gy x 3 fractions or 5–5.5 Gy x 4 fractions at 0.5 cm depth). All patients underwent hysterectomy with pathologically confirmed endometrioid adenocarcinoma, serous, clear cell or carcinosaroma histology. Eligible patients included all FIGO IB or II, FIGO 1A gr 2 -3 or FIGO 1A gr 1 with LVSI. Primary endpoint was health related quality of life (HRQOL) using the Global Health Score from the QLQ-C30 at 1 month. <h3>Results</h3> There were 108 patients enrolled from 5 institutions. At a median follow-up of 12.85 months, there have been no isolated vaginal recurrences. Table 1 shows the distribution of recurrences. Adverse events are shown in table 2. At the 1 month and 6 month time point, the QLQ-C30 scores in the experimental arm were non-inferior (P= p=0.00002). <h3>Conclusions</h3> This prospective randomized trial showed short course VCB is non-inferior to standard course VCB. While longer follow up data is necessary, short course VCB supports a growing literature in providing more options for women with early stage endometrial cancer. 

/pdf/o019-977-short-course-adjuvant-vaginal-cuff-brachytherapy-in-3u993jbu.pdf

William Small

Papers

Angiotensin Converting Enzyme (ACE) Inhibitor Associated Small BowelAngioedema and Ascites Presenting as Recurrent Acute Abdomen: A CaseReport

In Reply to Drs. Hannoun-Levi and Raoust

O019/#977 Short course adjuvant vaginal cuff brachytherapy in early endometrial cancer: adverse events and early patient reported outcomes