Wilson M. Compton

TL;DR: Substance use disorders and mood and anxiety disorders that develop independently of intoxication and withdrawal are among the most prevalent psychiatric disorders in the United States, suggesting that treatment for a comorbid mood or anxiety disorder should be withheld from individuals with substance use disorders.

TL;DR: Evidence is found for the effectiveness of cannabinoid drugs in treating nausea and in treating some forms of pain and spasticity, and 2 cannabinoid medications are approved by the US Food and Drug Administration for alleviating nausea induced by cancer chemotherapy.

TL;DR: To achieve the maximum benefit, addressing the overlap of opioids with multiple other substances is needed across the spectrum of prevention and treatment interventions, overdose reversal, public health surveillance, and research.

TL;DR: DSM-5's single dimension CUD measure may be more sensitive to diagnosis prevalence changes than the separate DSM-IV cannabis dependence and abuse categories and future diagnostic approaches to assessing CUD may benefit from quantitatively oriented criteria.

TL;DR: Practising pharmacists can be alert for signs of opioid misuse by patients as well as inappropriate prescribing or hazardous drug combinations that physicians may not be aware of and supply patients with information on risks of opioids, proper storage and disposal of medications, and the harms (and illegality) of sharing medications with other people.