A radiodiagnostic bisamido-bisthio ligand useful for producing Tc-labelled radiodiagnostic renal agents is described. The ligand forms a complex with the radionuclide 99m Tc suitable for administration as a radiopharmaceutical to obtain images of the kidney for diagnosis of kidney disfunction.

Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents

The present invention relates to a novel family of Technetium chelating agents (ligands) based upon amide and mercaptide donor groups.

Chelating agents for technetium-99M

A method of imaging organs with 99m Tc radiopharmaceuticals, especially of hepatobiliary imaging and negative myocardial infarct imaging in a mammal which comprises administering to the mammal a hepatobiliary or myocardial imaging amount of a cationic lipophilic complex of Tc-99m and detecting the Tc-99m complex in the mammal. A method for the preparation of cationic lipophilic complexes of Tc-99m.

Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging

The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ-specific substance, or an organ-specific substance which has been pretreated or coupled to a complexing agent for technetium-99m, is mixed with [99m]-pertechnetate and a complex-stabilized reducing agent.

Process for the preparation of an organ-specific substance labeled with technetium-99m

A complex of a chelating agent is formed and labelled with technetium-99m. The chelating agent is either an ethylenediamine carboxylic acid or its salt having a phenolic group at each end of the molecule such as EDDHA and HBED or alternatively the phenolic amino carboxylic acid or its salt having a single phenolate group such as HBG or HBS. The complex is a stannous complex which when labelled with technetium-99m has a good balance of lipo-solubility and waater-solubility to permit hepato-biliary imaging. The radiopharmaceutical may be useful for assessing hepatobiliary function in animals including human beings. A particularly useful chelating agent is ethylene-bis-(α-imino-2-hydroxy-5-bromophenyl acetic acid).

Phenolic amino-carboxylic acid complexes for forming radiopharmaceuticals

A radiopharmaceutical comprising 2-mercaptoisobutyric acid chelating reduced technetium-99m for scintigraphically imaging the liver and biliary tract morphology and function and to a method for instantly making the radiopharmaceutical.

Winchell Harry S

Papers

Hepato-biliary radiopharmaceutical comprising 2-mercaptoisobutyric acid chelating reduced technetium-99m