W
Winile W. Mavuso
Researcher at University of Cape Town
Publications - 4
Citations - 393
Winile W. Mavuso is an academic researcher from University of Cape Town. The author has contributed to research in topics: Infrared spectroscopy & Reaction rate. The author has an hindex of 3, co-authored 4 publications receiving 377 citations.
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The mechanism of beta-hematin formation in acetate solution. Parallels between hemozoin formation and biomineralization processes.
TL;DR: The formation of beta-hematin closely parallels many mineralization processes, and this suggests that hemozoin formation may be a unique biomineralization process.
Journal ArticleDOI
Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX
TL;DR: Interactions of chloroquine, quinine, and 9-epiquinine with Fe(III)PPIX are shown to remain strong at pH 5.6, the approximate pH of the food vacuole of the malaria parasite which is believed to be the locus of drug activity.
Journal ArticleDOI
Characterisation of synthetic β-haematin and effects of the antimalarial drugs quinidine, halofantrine, desbutylhalofantrine and mefloquine on its formation
TL;DR: Infrared spectroscopy, elemental analysis and X-ray powder diffraction show that the product of 30 min of reaction of haematin is identical to beta-haematin prepared in 4.5 M acetate, and the antimalarial drugs quinidine, halofantrine, desbutylhal ofantrine and mefloquine were found to inhibit formation of beta- Haematin.