W
Wouter Beertsen
Researcher at Academic Center for Dentistry Amsterdam
Publications - 89
Citations - 4194
Wouter Beertsen is an academic researcher from Academic Center for Dentistry Amsterdam. The author has contributed to research in topics: Periodontal fiber & Cementum. The author has an hindex of 37, co-authored 89 publications receiving 4099 citations. Previous affiliations of Wouter Beertsen include University of Amsterdam.
Papers
More filters
Journal ArticleDOI
Degradation of collagen in the bone-resorbing compartment underlying the osteoclast involves both cysteine-proteinases and matrix metalloproteinases.
TL;DR: It is concluded that within the osteoclastic resorption lacuna both CPs and MMPs participate in the degradation of the collagenous bone matrix.
Journal ArticleDOI
Enamel matrix-derived protein stimulates attachment of periodontal ligament fibroblasts and enhances alkaline phosphatase activity and transforming growth factor beta1 release of periodontal ligament and gingival fibroblasts.
Monique T. Van der Pauw,Monique T. Van der Pauw,Theo van den Bos,Vincent Everts,Vincent Everts,Wouter Beertsen +5 more
TL;DR: The results indicate that HPLF and HGF respond differently to EMP, which might contribute, during the initial stages of periodontal healing, to selective outgrowth and colonization of exposed root surfaces in vivo.
Journal ArticleDOI
Fine structure of fibroblasts in the periodontal ligament of the rat incisor and their possible role in tooth eruption
TL;DR: Data are presented which support the view that fibroblasts in the periodontal ligament of the incisor, apart from synthesizing collagen, are also engaged in degrading collagen fibres, necessary to maintain the structural integrity of the ligament in a dynamic situation.
Journal ArticleDOI
Cysteine proteinases and matrix metalloproteinases play distinct roles in the subosteoclastic resorption zone.
TL;DR: In this paper, the authors investigated the effect of low molecular weight inhibitors of cysteine proteinases (E-64, Z-Phe-Tyr(O-t-Bu)CHN2 or CA074[Me) on the activity of matrix metalloproteinases (MMPs).
Journal ArticleDOI
Phagocytosis of bone collagen by osteoclasts in two cases of pycnodysostosis
TL;DR: Electron microscopic examination of bone biopsies obtained from two patients suffering from pycnodysostosis revealed that osteoclasts contained (sometimes large) cytoplasmic vacuoles filled with bone collagen fibrils, suggesting that bone matrix had been phagocytosed and subsequently exposed to hydrolytic enzymes of the lysosomal apparatus.